| 1 | Mon Nov 4 | vs Charleston | L80-90 | 0-1 | .000 | - | | Banterra Center · Carbondale, IL |
| 2 | Fri Nov 8 | vs TBD | W86-64 | 1-1 | .500 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 3 | Thu Nov 14 | at Oklahoma St | L78-85 | 1-2 | .333 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Mon Nov 18 | vs N Dakota St | W69-44 | 2-2 | .500 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 5 | Fri Nov 22 | at #21Florida | L68-93 | 2-3 | .400 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 6 | Mon Nov 25 | at Louisiana Tech | L79-85 (OT) | 2-4 | .333 | - | | Thomas Assembly Center · Ruston, LA |
| 7 | Tue Nov 26 | vs E Kentucky | L72-77 | 2-5 | .286 | - | | Banterra Center · Carbondale, IL |
| 8 | Wed Nov 27 | atTBD | W81-54 | 3-5 | .375 | - | | Hertz Arena |
| 9 | Tue Dec 3 | vs Bradley | L60-83 | 3-6 | .333 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 10 | Sat Dec 7 | vs So Indiana | W73-70 | 4-6 | .400 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 11 | Sat Dec 14 | at Austin Peay | W65-60 | 5-6 | .455 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 12 | Sat Dec 21 | vs High Point | L81-94 | 5-7 | .417 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 13 | Sun Dec 29 | at Northern Iowa | L67-78 | 5-8 | .385 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 14 | Wed Jan 1 | vs Evansville | L53-68 | 5-9 | .357 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 15 | Sun Jan 5 | at Illinois St | L54-85 | 5-10 | .333 | - | ESPN+ | Redbird Arena · Normal, IL |
| 16 | Wed Jan 8 | at Belmont | L86-90 | 5-11 | .313 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 17 | Sat Jan 11 | vs Missouri St | W88-78 (OT) | 6-11 | .353 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 18 | Wed Jan 15 | atMissouri St | W73-51 | 7-11 | .389 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 19 | Sat Jan 18 | vsNorthern Iowa | W73-49 | 8-11 | .421 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 20 | Wed Jan 22 | vs Murray St | L64-74 | 8-12 | .400 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 21 | Sat Jan 25 | at UIC | W89-85 | 9-12 | .429 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 22 | Tue Jan 28 | at Valparaiso | W79-75 | 10-12 | .455 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 23 | Sat Feb 1 | vs Drake | L65-75 | 10-13 | .435 | - | ESPNU | Banterra Center · Carbondale, IL |
| 24 | Wed Feb 5 | atEvansville | W68-59 | 11-13 | .458 | - | ESPN+ | Ford Center · Evansville, IN |
| 25 | Sat Feb 8 | vsUIC | W79-67 | 12-13 | .480 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 26 | Wed Feb 12 | atBradley | L64-78 | 12-14 | .462 | - | ESPN+ | Carver Arena · Peoria, IL |
| 27 | Sat Feb 15 | vsBelmont | L68-73 | 12-15 | .444 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 28 | Wed Feb 19 | atMurray St | L60-62 | 12-16 | .429 | - | ESPN+ | CFSB Center · Murray, KY |
Indiana St