| 2 | Tue Dec 15 | at Akron | W81-74 | 1-0 | 1.000 | - | | James A. Rhodes Arena · Akron, OH |
| 3 | Sat Dec 19 | vs Hofstra | W77-69 | 2-0 | 1.000 | - | | Reilly Center · Saint Bonaventure, NY |
| 5 | Wed Dec 30 | at Rhode Island | L57-63 | 2-1 | .667 | - | | Ryan Center · Kingston, RI |
| 6 | Sat Jan 2 | at Richmond | W69-66 | 3-1 | .750 | - | CBS | Robins Center · Richmond, VA |
| 7 | Wed Jan 6 | vs Saint Joseph's | W83-57 | 4-1 | .800 | - | | Reilly Center · Saint Bonaventure, NY |
| 8 | Sat Jan 9 | vs G Washington | PPD | 16-5 | .762 | - | NBCSN | Reilly Center · Saint Bonaventure, NY |
| 9 | Wed Jan 13 | at Fordham | W68-54 | 5-1 | .833 | - | | Rose Hill Gymnasium · Bronx, NY |
| 10 | Fri Jan 15 | vs Duquesne | W62-48 | 6-1 | .857 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 11 | Wed Jan 20 | vs VCU | W70-54 | 7-1 | .875 | - | | Reilly Center · Saint Bonaventure, NY |
| 12 | Sat Jan 23 | atDuquesne | W65-61 | 8-1 | .889 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Sat Jan 30 | vs George Mason | W84-67 | 9-1 | .900 | - | | Reilly Center · Saint Bonaventure, NY |
| 15 | Sat Feb 6 | at Saint Louis | L59-70 | 9-2 | .818 | - | | Chaifetz Arena · St. Louis, MO |
| 16 | Tue Feb 9 | vs La Salle | W86-73 | 10-2 | .833 | - | | Reilly Center · Saint Bonaventure, NY |
| 17 | Fri Feb 12 | atVCU | L64-67 | 10-3 | .769 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 20 | Sun Feb 21 | vs Davidson | W69-58 | 11-3 | .786 | - | | Reilly Center · Saint Bonaventure, NY |
| 21 | Wed Feb 24 | atDavidson | W56-53 | 12-3 | .800 | - | | John M. Belk Arena · Davidson, NC |
| 22 | Fri Feb 26 | vsG Washington | W88-41 | 13-3 | .813 | - | | Reilly Center · Saint Bonaventure, NY |
| 23 | Mon Mar 1 | vs Dayton | L52-55 | 13-4 | .765 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 24 | Fri Mar 5 | vsDuquesne | W75-59 | 14-4 | .778 | - | NBCSN | Reilly Center · Saint Bonaventure, NY |
| 25 | Sat Mar 6 | vsSaint Louis | W71-53 | 15-4 | .789 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 26 | Sun Mar 14 | vsVCU | W74-65 | 16-4 | .800 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 27 | Sat Mar 20 | at #8LSU | L61-76 | 16-5 | .762 | #9 | TNT | Pete Maravich Assembly Center · Baton Rouge, LA |
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