| 1 | Mon Nov 7 | vs St Francis PA | W71-58 | 1-0 | 1.000 | - | | Reilly Center · Saint Bonaventure, NY |
| 2 | Sat Nov 12 | atCanisius | L80-84 (OT) | 1-1 | .500 | - | | Koessler Athletic Center · Buffalo, NY |
| 3 | Tue Nov 15 | atS Dakota St | L62-66 | 1-2 | .333 | - | | Frost Arena · Brookings, SD |
| 4 | Sat Nov 19 | vsBowling Green | W81-68 | 2-2 | .500 | - | | Reilly Center · Saint Bonaventure, NY |
| 5 | Tue Nov 22 | vsSo Indiana | W80-66 | 3-2 | .600 | - | | Reilly Center · Saint Bonaventure, NY |
| 6 | Fri Nov 25 | vsNotre Dame | W63-51 | 4-2 | .667 | - | | Reilly Center · Saint Bonaventure, NY |
| 7 | Wed Nov 30 | vsMTSU | W71-64 | 5-2 | .714 | - | | Reilly Center · Saint Bonaventure, NY |
| 8 | Sat Dec 3 | atBuffalo | L66-83 | 5-3 | .625 | - | | Alumni Arena · Buffalo, NY |
| 9 | Wed Dec 7 | vsCleveland St | W61-42 | 6-3 | .667 | - | | Reilly Center · Saint Bonaventure, NY |
| 10 | Sun Dec 11 | atIona | L57-72 | 6-4 | .600 | - | | Hynes Athletics Center · New Rochelle, NY |
| 11 | Fri Dec 16 | vsFGCU | L58-71 | 6-5 | .545 | - | | Reilly Center · Saint Bonaventure, NY |
| 12 | Mon Dec 19 | atSiena | L70-76 | 6-6 | .500 | - | | MVP Arena · Albany, NY |
| 13 | Wed Dec 21 | atNorthern Iowa | L52-62 | 6-7 | .462 | - | | McLeod Center · Cedar Falls, IA |
| 14 | Sat Dec 31 | vsUMass | W83-64 | 7-7 | .500 | - | | Reilly Center · Saint Bonaventure, NY |
| 15 | Wed Jan 4 | vsGeorge Mason | W73-69 | 8-7 | .533 | - | | Reilly Center · Saint Bonaventure, NY |
| 16 | Sat Jan 7 | atSaint Louis | L55-78 | 8-8 | .500 | - | | Chaifetz Arena · St. Louis, MO |
| 17 | Wed Jan 11 | atRhode Island | L67-68 | 8-9 | .471 | - | | Ryan Center · Kingston, RI |
| 18 | Sat Jan 14 | vsRichmond | W71-63 | 9-9 | .500 | - | | Reilly Center · Saint Bonaventure, NY |
| 19 | Wed Jan 18 | vsDuquesne | W65-56 | 10-9 | .526 | - | | Reilly Center · Saint Bonaventure, NY |
| 20 | Sat Jan 21 | atLoyola Chicago | L55-67 | 10-10 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Wed Jan 25 | vsFordham | L68-79 | 10-11 | .476 | - | | Reilly Center · Saint Bonaventure, NY |
| 22 | Sat Jan 28 | atVCU | W61-58 | 11-11 | .500 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 23 | Wed Feb 1 | atRichmond | W66-62 | 12-11 | .522 | - | | Robins Center · Richmond, VA |
| 24 | Sat Feb 4 | vsDayton | W68-59 | 13-11 | .542 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 25 | Wed Feb 8 | vsLa Salle | L70-76 | 13-12 | .520 | - | | Reilly Center · Saint Bonaventure, NY |
| 26 | Sat Feb 11 | atDuquesne | L54-56 | 13-13 | .500 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Wed Feb 15 | atFordham | L63-78 | 13-14 | .481 | - | | Rose Hill Gymnasium · Bronx, NY |
| 28 | Sun Feb 19 | vsG Washington | L81-83 (OT) | 13-15 | .464 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 29 | Wed Feb 22 | atDavidson | L61-74 | 13-16 | .448 | - | | John M. Belk Arena · Davidson, NC |
| 30 | Sun Feb 26 | vsSaint Joseph's | W89-76 | 14-16 | .467 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 31 | Sat Mar 4 | atUMass | L60-71 | 14-17 | .452 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 32 | Wed Mar 8 | atDavidson | L54-65 | 14-18 | .438 | - | USA Net | John M. Belk Arena · Davidson, NC |
