| 1 | Mon Nov 3 | vs Bradley | W69-63 | 1-0 | 1.000 | - | YouTube | Reilly Center · Saint Bonaventure, NY |
| 2 | Sat Nov 8 | vsCanisius | W89-70 | 2-0 | 1.000 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 3 | Wed Nov 12 | vsSiena | W75-66 | 3-0 | 1.000 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 4 | Sat Nov 15 | vsYoungstown St | W84-80 | 4-0 | 1.000 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 5 | Thu Nov 20 | vsRobert Morris | W75-61 | 5-0 | 1.000 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 6 | Tue Nov 25 | at16UNC | L70-85 | 5-1 | .833 | - | FS1 | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Thu Nov 27 | atE Carolina | W67-58 | 6-1 | .857 | - | FS1 | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Sun Nov 30 | atFAU | W70-65 | 7-1 | .875 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 9 | Wed Dec 3 | vsTBD | W83-43 | 8-1 | .889 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 10 | Sat Dec 6 | atBuffalo | W77-69 | 9-1 | .900 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 11 | Wed Dec 10 | vsColgate | W85-77 | 10-1 | .909 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 12 | Sat Dec 13 | atOhio | L83-88 (OT) | 10-2 | .833 | - | | Convocation Center (OH) · Athens, OH |
| 13 | Sat Dec 20 | vsLe Moyne | W92-81 | 11-2 | .846 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 14 | Wed Dec 31 | atVCU | L82-89 | 11-3 | .786 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 15 | Wed Jan 7 | vsRichmond | L80-89 | 11-4 | .733 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 16 | Sat Jan 10 | vsFordham | L77-81 | 11-5 | .688 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 17 | Wed Jan 14 | atSaint Joseph's | L64-68 | 11-6 | .647 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Sat Jan 17 | atLa Salle | L74-78 | 11-7 | .611 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 19 | Tue Jan 20 | vsLoyola Chicago | W84-70 | 12-7 | .632 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 20 | Fri Jan 23 | vs24Saint Louis | L62-97 | 12-8 | .600 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 21 | Wed Jan 28 | atDuquesne | W87-79 | 13-8 | .619 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sat Jan 31 | vsGeorge Mason | L73-77 | 13-9 | .591 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 23 | Tue Feb 3 | atDayton | L70-72 | 13-10 | .565 | - | CBSSN | UD Arena · Dayton, OH |
| 24 | Sat Feb 7 | atFordham | W70-67 | 14-10 | .583 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 25 | Sat Feb 14 | vsDuquesne | L73-78 | 14-11 | .560 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 26 | Wed Feb 18 | vsSaint Joseph's | L65-71 | 14-12 | .538 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 27 | Sat Feb 21 | atRichmond | L94-99 | 14-13 | .519 | - | ESPN+ | Robins Center · Richmond, VA |
| 28 | Thu Feb 26 | vsRhode Island | W94-76 | 15-13 | .536 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 29 | Sat Feb 28 | atGeorge Mason | L58-71 | 15-14 | .517 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
