| 1 | Mon Nov 6 | vs Longwood | W73-69 | 1-0 | 1.000 | - | | Reilly Center · Saint Bonaventure, NY |
| 2 | Sat Nov 11 | vsCanisius | L67-70 | 1-1 | .500 | - | | Reilly Center · Saint Bonaventure, NY |
| 3 | Thu Nov 16 | vsOklahoma St | W66-64 | 2-1 | .667 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 4 | Fri Nov 17 | vsAuburn | L60-77 | 2-2 | .500 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 5 | Wed Nov 22 | vsBucknell | W67-61 | 3-2 | .600 | - | | Reilly Center · Saint Bonaventure, NY |
| 6 | Sat Nov 25 | vsMiami OH | W90-60 | 4-2 | .667 | - | | Reilly Center · Saint Bonaventure, NY |
| 7 | Sat Dec 2 | atBuffalo | W80-65 | 5-2 | .714 | - | | Alumni Arena · Buffalo, NY |
| 8 | Wed Dec 6 | atNiagara | W94-60 | 6-2 | .750 | - | | Gallagher Center · Niagara Falls, NY |
| 9 | Sat Dec 9 | vsSiena | W89-56 | 7-2 | .778 | - | | Reilly Center · Saint Bonaventure, NY |
| 10 | Sat Dec 16 | vs#15FAU | L54-64 | 7-3 | .700 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 11 | Fri Dec 22 | vsBinghamton | W90-64 | 8-3 | .727 | - | | Reilly Center · Saint Bonaventure, NY |
| 12 | Sat Dec 30 | atAkron | W62-61 | 9-3 | .750 | - | | James A. Rhodes Arena · Akron, OH |
| 13 | Wed Jan 3 | atVCU | W89-78 | 10-3 | .769 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 14 | Sat Jan 6 | atRichmond | L54-65 | 10-4 | .714 | - | | Robins Center · Richmond, VA |
| 15 | Sat Jan 13 | vsFordham | L74-80 | 10-5 | .667 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 16 | Wed Jan 17 | vsRhode Island | W99-64 | 11-5 | .688 | - | | Reilly Center · Saint Bonaventure, NY |
| 17 | Sat Jan 20 | atGeorge Mason | L60-69 | 11-6 | .647 | - | | EagleBank Arena · Fairfax, VA |
| 18 | Tue Jan 23 | atDuquesne | L50-54 | 11-7 | .611 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 19 | Fri Jan 26 | vsSaint Joseph's | W91-72 | 12-7 | .632 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 20 | Tue Jan 30 | vsVCU | W67-62 | 13-7 | .650 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 21 | Fri Feb 2 | at#21Dayton | L71-76 | 13-8 | .619 | - | ESPN2 | UD Arena · Dayton, OH |
| 22 | Wed Feb 7 | vsUMass | W79-73 | 14-8 | .636 | - | | Reilly Center · Saint Bonaventure, NY |
| 23 | Sat Feb 10 | vsDuquesne | L69-75 | 14-9 | .609 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 24 | Wed Feb 14 | atFordham | W85-67 | 15-9 | .625 | - | | Rose Hill Gymnasium · Bronx, NY |
| 25 | Sat Feb 17 | vsDavidson | W81-80 (OT) | 16-9 | .640 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 26 | Wed Feb 21 | atLa Salle | L59-72 | 16-10 | .615 | - | | Tom Gola Arena · Philadelphia, PA |
| 27 | Sat Feb 24 | atUMass | W75-67 | 17-10 | .630 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 28 | Tue Feb 27 | vsLoyola Chicago | W79-64 | 18-10 | .643 | - | | Reilly Center · Saint Bonaventure, NY |
| 29 | Wed Mar 6 | atG Washington | L75-86 | 18-11 | .621 | - | | Charles E. Smith Center · Washington, D.C. |
| 30 | Sat Mar 9 | vsSaint Louis | L65-73 | 18-12 | .600 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 31 | Wed Mar 13 | vsLa Salle | W75-73 | 19-12 | .613 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 32 | Thu Mar 14 | atLoyola Chicago | W75-74 (2OT) | 20-12 | .625 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 33 | Sat Mar 16 | atDuquesne | L60-70 | 20-13 | .606 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
