| 1 | Tue Nov 5 | vs Ohio | L53-65 | 0-1 | .000 | - | | Reilly Center · Saint Bonaventure, NY |
| 2 | Fri Nov 8 | vs Vermont | L59-61 | 0-2 | .000 | - | | Reilly Center · Saint Bonaventure, NY |
| 3 | Tue Nov 12 | at Siena | L65-78 | 0-3 | .000 | - | | MVP Arena · Albany, NY |
| 4 | Sat Nov 16 | at Rutgers | W80-74 | 1-3 | .250 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 5 | Sat Nov 23 | at Canisius | L57-61 | 1-4 | .200 | - | | Koessler Athletic Center · Buffalo, NY |
| 6 | Tue Nov 26 | vs Mercer | W56-51 | 2-4 | .333 | - | | Reilly Center · Saint Bonaventure, NY |
| 7 | Sun Dec 1 | at San Diego | W70-61 | 3-4 | .429 | - | | Jenny Craig Pavilion · San Diego, CA |
| 8 | Mon Dec 2 | at FAU | W71-64 | 4-4 | .500 | - | | FAU Arena · Boca Raton, FL |
| 9 | Sat Dec 7 | vs Hofstra | W73-45 | 5-4 | .556 | - | | Reilly Center · Saint Bonaventure, NY |
| 10 | Sat Dec 14 | vs TBD | W75-50 | 6-4 | .600 | - | | Reilly Center · Saint Bonaventure, NY |
| 11 | Wed Dec 18 | vs Niagara | W87-70 | 7-4 | .636 | - | | Reilly Center · Saint Bonaventure, NY |
| 12 | Sat Dec 21 | at MTSU | W66-65 | 8-4 | .667 | - | | Murphy Center · Murfreesboro, TN |
| 13 | Mon Dec 30 | at Buffalo | L79-84 | 8-5 | .615 | - | | Alumni Arena · Buffalo, NY |
| 14 | Sun Jan 5 | at G Washington | W71-66 | 9-5 | .643 | - | | Charles E. Smith Center · Washington, D.C. |
| 15 | Wed Jan 8 | at George Mason | W61-49 | 10-5 | .667 | - | | EagleBank Arena · Fairfax, VA |
| 16 | Sat Jan 11 | vs Fordham | W64-44 | 11-5 | .688 | - | | Reilly Center · Saint Bonaventure, NY |
| 17 | Wed Jan 15 | vs UMass | W74-61 | 12-5 | .706 | - | | Reilly Center · Saint Bonaventure, NY |
| 18 | Sat Jan 18 | at VCU | L63-91 | 12-6 | .667 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 19 | Wed Jan 22 | at #7Dayton | L60-86 | 12-7 | .632 | - | CBS | UD Arena · Dayton, OH |
| 20 | Sat Jan 25 | vs Rhode Island | L75-81 | 12-8 | .600 | - | | Reilly Center · Saint Bonaventure, NY |
| 21 | Wed Jan 29 | atFordham | W62-55 (OT) | 13-8 | .619 | - | | Rose Hill Gymnasium · Bronx, NY |
| 22 | Sat Feb 1 | vsGeorge Mason | W74-65 | 14-8 | .636 | - | | Reilly Center · Saint Bonaventure, NY |
| 23 | Wed Feb 5 | vsG Washington | W72-47 | 15-8 | .652 | - | | Reilly Center · Saint Bonaventure, NY |
| 24 | Sat Feb 8 | at Duquesne | W83-80 | 16-8 | .667 | - | NBCSN | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Tue Feb 11 | at Saint Joseph's | W74-56 | 17-8 | .680 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 26 | Fri Feb 14 | vs Davidson | L64-93 | 17-9 | .654 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 27 | Sat Feb 22 | vs Richmond | W75-71 | 18-9 | .667 | - | | Reilly Center · Saint Bonaventure, NY |
| 28 | Wed Feb 26 | vsDuquesne | L77-81 (OT) | 18-10 | .643 | - | | Reilly Center · Saint Bonaventure, NY |
| 29 | Sat Feb 29 | at La Salle | L65-73 | 18-11 | .621 | - | | Tom Gola Arena · Philadelphia, PA |
| 30 | Wed Mar 4 | vsSaint Joseph's | W89-73 | 19-11 | .633 | - | | Reilly Center · Saint Bonaventure, NY |
| 31 | Sat Mar 7 | at Saint Louis | L49-72 | 19-12 | .613 | - | | Chaifetz Arena · St. Louis, MO |
