| 1 | Tue Nov 9 | vs Siena | W75-47 | 1-0 | 1.000 | #23 | | Reilly Center · Saint Bonaventure, NY |
| 2 | Sun Nov 14 | vsCanisius | W69-60 | 2-0 | 1.000 | #23 | | Reilly Center · Saint Bonaventure, NY |
| 3 | Thu Nov 18 | atBoise St | W67-61 | 3-0 | 1.000 | - | ESPN2 | TD Arena · Charleston, SC |
| 4 | Fri Nov 19 | atClemson | W68-65 | 4-0 | 1.000 | - | ESPN2 | TD Arena · Charleston, SC |
| 5 | Sun Nov 21 | atMarquette | W70-54 | 5-0 | 1.000 | - | ESPN | TD Arena · Charleston, SC |
| 6 | Sat Nov 27 | vsNorthern Iowa | L80-90 | 5-1 | .833 | #16 | | Reilly Center · Saint Bonaventure, NY |
| 7 | Wed Dec 1 | vsCoppin St | W93-81 | 6-1 | .857 | - | | Reilly Center · Saint Bonaventure, NY |
| 8 | Sat Dec 4 | vsBuffalo | W68-65 | 7-1 | .875 | - | | Reilly Center · Saint Bonaventure, NY |
| 9 | Wed Dec 8 | vsLoyola MD | W84-71 | 8-1 | .889 | - | | Reilly Center · Saint Bonaventure, NY |
| 10 | Sat Dec 11 | atUConn | L64-74 | 8-2 | .800 | - | ESPN2 | Prudential Center · Newark, NJ |
| 11 | Fri Dec 17 | atVirginia Tech | L49-86 | 8-3 | .727 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 14 | Sun Jan 2 | atDayton | PPD | 23-10 | .697 | - | | UD Arena · Dayton, OH |
| 15 | Wed Jan 5 | vsFordham | PPD | 23-10 | .697 | - | | Reilly Center · Saint Bonaventure, NY |
| 16 | Tue Jan 11 | atLa Salle | W80-76 (OT) | 9-3 | .750 | - | | Tom Gola Arena · Philadelphia, PA |
| 17 | Fri Jan 14 | vsVCU | W73-53 | 10-3 | .769 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 18 | Tue Jan 18 | atDayton | L50-68 | 10-4 | .714 | - | | UD Arena · Dayton, OH |
| 19 | Fri Jan 21 | atDuquesne | W64-56 | 11-4 | .733 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Wed Jan 26 | atGeorge Mason | L66-75 | 11-5 | .688 | - | | EagleBank Arena · Fairfax, VA |
| 21 | Sat Jan 29 | vsSaint Joseph's | W80-69 | 12-5 | .706 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 22 | Tue Feb 1 | vsDavidson | L76-81 | 12-6 | .667 | - | CBSSN | Reilly Center · Saint Bonaventure, NY |
| 23 | Fri Feb 4 | atRichmond | L61-71 | 12-7 | .632 | - | ESPN2 | Robins Center · Richmond, VA |
| 24 | Tue Feb 8 | vsFordham | W76-51 | 13-7 | .650 | - | | Reilly Center · Saint Bonaventure, NY |
| 25 | Fri Feb 11 | atSaint Louis | W68-61 | 14-7 | .667 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 26 | Mon Feb 14 | vsSaint Louis | W83-79 | 15-7 | .682 | - | CBSSN | Reilly Center · Saint Bonaventure, NY |
| 27 | Wed Feb 16 | vsUMass | W83-71 | 16-7 | .696 | - | | Reilly Center · Saint Bonaventure, NY |
| 28 | Sat Feb 19 | vsDuquesne | W81-55 | 17-7 | .708 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 29 | Tue Feb 22 | vsRhode Island | W73-55 | 18-7 | .720 | - | CBSSN | Reilly Center · Saint Bonaventure, NY |
| 30 | Sat Feb 26 | atSaint Joseph's | W54-52 | 19-7 | .731 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 31 | Tue Mar 1 | atVCU | L51-74 | 19-8 | .704 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 32 | Fri Mar 4 | vsRichmond | W72-65 | 20-8 | .714 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 33 | Fri Mar 11 | vsSaint Louis | L56-57 | 20-9 | .690 | - | USA Net | Capital One Arena · Washington, D.C. |
| 32 | Tue Mar 15 | atColorado | W76-68 | 21-9 | .700 | - | ESPN2 | CU Events Center · Boulder, CO |
| 33 | Sun Mar 20 | atOklahoma | W70-68 | 22-9 | .710 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 34 | Tue Mar 22 | atVirginia | W52-51 | 23-9 | .719 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 35 | Tue Mar 29 | atXavier | L77-84 | 23-10 | .697 | - | ESPN | Cintas Center · Cincinnati, OH |
