| 1 | Mon Nov 3 | vs N'Western St | W98-68 | 1-0 | 1.000 | - | SECN+ | Reed Arena · College Station, TX |
| 2 | Thu Nov 6 | vsTexas So | W104-70 | 2-0 | 1.000 | - | SECN+ | Reed Arena · College Station, TX |
| 3 | Sun Nov 9 | atOklahoma St | L63-87 | 2-1 | .667 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Fri Nov 14 | vsUCF | L74-86 | 2-2 | .500 | - | SECN+ | Reed Arena · College Station, TX |
| 5 | Tue Nov 18 | vsMontana | W86-81 | 3-2 | .600 | - | SECN+ | Reed Arena · College Station, TX |
| 6 | Fri Nov 21 | vsManhattan | W109-68 | 4-2 | .667 | - | SECN+ | Reed Arena · College Station, TX |
| 7 | Tue Nov 25 | vsMiss Valley St | W120-84 | 5-2 | .714 | - | SECN+ | Reed Arena · College Station, TX |
| 8 | Fri Nov 28 | atFlorida St | W95-59 | 6-2 | .750 | - | ESPN2 | Benchmark International Arena · Tampa, FL |
| 9 | Tue Dec 2 | atPitt | W81-73 | 7-2 | .778 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 7 | atSMU | L80-93 (OT) | 7-3 | .700 | - | ESPN2 | College Park Center · Arlington, TX |
| 11 | Sun Dec 14 | vsJacksonville | W112-75 | 8-3 | .727 | - | SEC Network | Reed Arena · College Station, TX |
| 12 | Sun Dec 21 | vsE Texas A&M | W118-77 | 9-3 | .750 | - | SECN+ | Reed Arena · College Station, TX |
| 13 | Mon Dec 29 | vsPrairie View | W111-82 | 10-3 | .769 | - | SECN+ | Reed Arena · College Station, TX |
| 14 | Sat Jan 3 | vsLSU | W75-72 | 11-3 | .786 | - | ESPNU | Reed Arena · College Station, TX |
| 15 | Tue Jan 6 | atAuburn | W90-88 | 12-3 | .800 | - | SEC Network | Neville Arena · Auburn, AL |
| 16 | Sat Jan 10 | vsOklahoma | W83-76 | 13-3 | .813 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Tue Jan 13 | at24Tennessee | L82-87 (2OT) | 13-4 | .765 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 17 | atTexas | W74-70 | 14-4 | .778 | - | ESPN | Moody Center · Austin, TX |
| 19 | Wed Jan 21 | vsMississippi St | W88-68 | 15-4 | .789 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 24 | vsSouth Carolina | W92-69 | 16-4 | .800 | - | SECN+ | Reed Arena · College Station, TX |
| 21 | Sat Jan 31 | atGeorgia | W92-77 | 17-4 | .810 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 22 | Wed Feb 4 | atAlabama | L97-100 | 17-5 | .773 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Sat Feb 7 | vs17Florida | L67-86 | 17-6 | .739 | - | SEC Network | Reed Arena · College Station, TX |
| 24 | Wed Feb 11 | vsMissouri | L85-86 | 17-7 | .708 | - | SEC Network | Reed Arena · College Station, TX |
| 25 | Sat Feb 14 | at19Vanderbilt | L69-82 | 17-8 | .680 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 26 | Wed Feb 18 | vsOle Miss | W80-77 | 18-8 | .692 | - | SEC Network | Reed Arena · College Station, TX |
| 27 | Sat Feb 21 | atOklahoma | W75-71 | 19-8 | .704 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 28 | Wed Feb 25 | at20Arkansas | L84-99 | 19-9 | .679 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 29 | Sat Feb 28 | vsTexas | L70-76 | 19-10 | .655 | - | ESPN2 | Reed Arena · College Station, TX |
| 30 | Tue Mar 3 | vsKentucky | W96-85 | 20-10 | .667 | - | ESPN2 | Reed Arena · College Station, TX |
| 31 | Sat Mar 7 | atLSU | W94-91 (3OT) | 21-10 | .677 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 32 | Thu Mar 12 | vsOklahoma | L63-83 | 21-11 | .656 | - | SEC Network | Reed Arena · College Station, TX |
| R1 | Thu Mar 19 | at7Saint Mary's | W63-50 | 22-11 | .667 | #10 | truTV | Paycom Center · Oklahoma City, OK |
| R2 | Sat Mar 21 | at2Houston | L57-88 | 22-12 | .647 | #10 | TNT | Paycom Center · Oklahoma City, OK |
