| 1 | Mon Nov 4 | at UCF | L61-64 | 0-1 | .000 | #13 | ESPN+ | Addition Financial Arena · Orlando, FL |
| 2 | Fri Nov 8 | vs E Texas A&M | W87-55 | 1-1 | .500 | #13 | ESPN+ | Reed Arena · College Station, TX |
| 3 | Mon Nov 11 | vs Lamar | W97-71 | 2-1 | .667 | #23 | ESPN+ | Reed Arena · College Station, TX |
| 4 | Fri Nov 15 | vs #21Ohio State | W78-64 | 3-1 | .750 | #23 | SEC Network | Reed Arena · College Station, TX |
| 5 | Wed Nov 20 | vs Southern | W71-54 | 4-1 | .800 | #23 | ESPN+ | Reed Arena · College Station, TX |
| 6 | Tue Nov 26 | at Oregon | L70-80 | 4-2 | .667 | #20 | TBS | Matthew Knight Arena · Eugene, OR |
| 7 | Wed Nov 27 | vs #21Creighton | W77-73 | 5-2 | .714 | #20 | Max | Reed Arena · College Station, TX |
| 8 | Sat Nov 30 | at Rutgers | W81-77 | 6-2 | .750 | #20 | truTV | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Tue Dec 3 | vs Wake Forest | W57-44 | 7-2 | .778 | #22 | ESPN2 | Reed Arena · College Station, TX |
| 10 | Sun Dec 8 | at Texas Tech | W72-67 | 8-2 | .800 | #22 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 11 | Sat Dec 14 | at #11Purdue | W70-66 | 9-2 | .818 | #17 | CBS | Mackey Arena · West Lafayette, IN |
| 12 | Fri Dec 20 | vs Hou Christian | W77-45 | 10-2 | .833 | #12 | ESPN+ | Reed Arena · College Station, TX |
| 13 | Sat Dec 28 | vs Abilene Chrstn | W92-54 | 11-2 | .846 | #13 | SEC Network | Reed Arena · College Station, TX |
| 14 | Sat Jan 4 | vs Texas | W80-60 | 12-2 | .857 | #13 | SEC Network | Reed Arena · College Station, TX |
| 15 | Wed Jan 8 | at #17Oklahoma | W80-78 | 13-2 | .867 | #10 | SEC Network | Lloyd Noble Center · Norman, OK |
| 16 | Sat Jan 11 | vs #5Alabama | L88-94 | 13-3 | .813 | #10 | ESPN | Reed Arena · College Station, TX |
| 17 | Tue Jan 14 | at #8Kentucky | L69-81 | 13-4 | .765 | #11 | ESPN2 | Rupp Arena · Lexington, KY |
| 18 | Sat Jan 18 | vs LSU | W68-57 | 14-4 | .778 | #11 | SEC Network | Reed Arena · College Station, TX |
| 19 | Wed Jan 22 | at #16Ole Miss | W63-62 | 15-4 | .789 | #13 | ESPN2 | SJB Pavilion · Oxford, MS |
| 20 | Sat Jan 25 | atTexas | L69-70 | 15-5 | .750 | #13 | ESPN2 | Moody Center · Austin, TX |
| 21 | Tue Jan 28 | vsOklahoma | W75-68 | 16-5 | .762 | #13 | SEC Network | Reed Arena · College Station, TX |
| 22 | Sat Feb 1 | at South Carolina | W76-72 | 17-5 | .773 | #13 | SEC Network | Colonial Life Arena · Columbia, SC |
| 23 | Sat Feb 8 | at #15Missouri | W67-64 | 18-5 | .783 | #10 | SEC Network | Mizzou Arena · Columbia, MO |
| 24 | Tue Feb 11 | vs Georgia | W69-53 | 19-5 | .792 | #8 | SEC Network | Reed Arena · College Station, TX |
| 25 | Sat Feb 15 | vs Arkansas | W69-61 | 20-5 | .800 | #8 | ESPN | Reed Arena · College Station, TX |
| 26 | Tue Feb 18 | at #21Mississippi St | L54-70 | 20-6 | .769 | #7 | SEC Network | Humphrey Coliseum · Starkville, MS |
#6Tennessee
Vanderbilt
#2Florida
#1Auburn