| 1 | Mon Nov 6 | vs TBD | W105-66 | 1-0 | 1.000 | - | | Trask Coliseum · Wilmington, NC |
| 2 | Sat Nov 11 | at UNC Asheville | W83-66 | 2-0 | 1.000 | - | | Kimmel Arena · Asheville, NC |
| 3 | Tue Nov 14 | vsTBD | W116-80 | 3-0 | 1.000 | - | | Trask Coliseum · Wilmington, NC |
| 4 | Mon Nov 20 | vs Murray St | W83-81 (OT) | 4-0 | 1.000 | - | | Trask Coliseum · Wilmington, NC |
| 5 | Tue Nov 21 | at Appalachian St | L56-86 | 4-1 | .800 | - | | Holmes Convocation Center · Boone, NC |
| 6 | Sat Nov 25 | at FGCU | W71-55 | 5-1 | .833 | - | | Alico Arena · Fort Myers, FL |
| 7 | Thu Nov 30 | at E Carolina | L66-74 | 5-2 | .714 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Sat Dec 2 | at #12Kentucky | W80-73 | 6-2 | .750 | - | SEC Network | Rupp Arena · Lexington, KY |
| 9 | Sun Dec 10 | vsTBD | W119-50 | 7-2 | .778 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Sat Dec 16 | at Georgia So | W82-77 | 8-2 | .800 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 11 | Thu Dec 21 | at Marshall | W78-69 | 9-2 | .818 | - | | Cam Henderson Center · Huntington, WV |
| 12 | Sat Dec 30 | at Arkansas | L90-106 | 9-3 | .750 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 13 | Thu Jan 4 | at Drexel | L63-78 | 9-4 | .692 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Sat Jan 6 | at Towson | L64-67 | 9-5 | .643 | - | | SECU Arena · Towson, MD |
| 15 | Thu Jan 11 | vs Monmouth | W69-56 | 10-5 | .667 | - | | Trask Coliseum · Wilmington, NC |
| 16 | Sun Jan 14 | vs Delaware | W79-74 | 11-5 | .688 | - | CBS | Trask Coliseum · Wilmington, NC |
| 17 | Thu Jan 18 | at Elon | W82-70 | 12-5 | .706 | - | | Schar Center · Elon, NC |
| 18 | Sat Jan 20 | vs Charleston | W78-69 | 13-5 | .722 | - | CBS | Trask Coliseum · Wilmington, NC |
| 19 | Thu Jan 25 | at Northeastern | W77-54 | 14-5 | .737 | - | | Matthews Arena · Boston, MA |
| 20 | Sat Jan 27 | at Stony Brook | L78-86 (OT) | 14-6 | .700 | - | CBS | Island FCU Arena · Stony Brook, NY |
| 21 | Thu Feb 1 | atCharleston | W80-74 | 15-6 | .714 | - | | TD Arena · Charleston, SC |
| 22 | Sat Feb 3 | vs Campbell | W77-74 | 16-6 | .727 | - | | Trask Coliseum · Wilmington, NC |
| 23 | Thu Feb 8 | vsDrexel | W75-56 | 17-6 | .739 | - | | Trask Coliseum · Wilmington, NC |
| 24 | Sat Feb 10 | at Hampton | W95-65 | 18-6 | .750 | - | | Convocation Center (VA) · Hampton, VA |
| 25 | Thu Feb 15 | vs NC A&T | W73-54 | 19-6 | .760 | - | | Trask Coliseum · Wilmington, NC |
| 26 | Sat Feb 17 | vsElon | L72-73 | 19-7 | .731 | - | | Trask Coliseum · Wilmington, NC |
| 27 | Thu Feb 22 | at William & Mary | W81-65 | 20-7 | .741 | - | | Kaplan Arena · Williamsburg, VA |
| 28 | Mon Feb 26 | atCampbell | L100-105 (2OT) | 20-8 | .714 | - | CBS | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 29 | Thu Feb 29 | vs Hofstra | L58-69 | 20-9 | .690 | - | | Trask Coliseum · Wilmington, NC |
| 30 | Sat Mar 2 | vsTowson | W75-64 | 21-9 | .700 | - | CBS | Trask Coliseum · Wilmington, NC |
| 31 | Sun Mar 10 | vsTowson | L56-66 | 21-10 | .677 | - | | Trask Coliseum · Wilmington, NC |
