| 1 | Mon Nov 4 | vs TBD | W143-91 | 1-0 | 1.000 | - | FloSports | Trask Coliseum · Wilmington, NC |
| 2 | Fri Nov 8 | vsGeorgia So | W92-84 | 2-0 | 1.000 | - | FloSports | Trask Coliseum · Wilmington, NC |
| 3 | Fri Nov 15 | atSC Upstate | W89-85 | 3-0 | 1.000 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 4 | Tue Nov 19 | at#1Kansas | L66-84 | 3-1 | .750 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Wed Nov 27 | vsColgate | L59-72 | 3-2 | .600 | - | | Trask Coliseum · Wilmington, NC |
| 6 | Fri Nov 29 | vsSam Houston | W69-60 | 4-2 | .667 | - | | Trask Coliseum · Wilmington, NC |
| 7 | Sat Nov 30 | vsAppalachian St | W76-61 | 5-2 | .714 | - | | Trask Coliseum · Wilmington, NC |
| 8 | Tue Dec 3 | atE Carolina | W67-53 | 6-2 | .750 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 9 | Sat Dec 7 | vsMarshall | W78-69 | 7-2 | .778 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Sat Dec 14 | atHoward | L83-88 | 7-3 | .700 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 11 | Wed Dec 18 | vsFGCU | W79-66 | 8-3 | .727 | - | | Trask Coliseum · Wilmington, NC |
| 12 | Sat Dec 21 | vsUNC Asheville | W85-74 | 9-3 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 13 | Sat Dec 28 | vsTBD | W99-47 | 10-3 | .769 | - | | Trask Coliseum · Wilmington, NC |
| 14 | Thu Jan 2 | vsTowson | L61-65 (OT) | 10-4 | .714 | - | | Trask Coliseum · Wilmington, NC |
| 15 | Sat Jan 4 | vsCampbell | W77-69 | 11-4 | .733 | - | | Trask Coliseum · Wilmington, NC |
| 16 | Thu Jan 9 | atMonmouth | W64-55 | 12-4 | .750 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 17 | Sat Jan 11 | atHofstra | L63-66 | 12-5 | .706 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 18 | Thu Jan 16 | vsNortheastern | W80-72 | 13-5 | .722 | - | | Trask Coliseum · Wilmington, NC |
| 19 | Mon Jan 20 | vsWilliam & Mary | W85-74 | 14-5 | .737 | - | CBSSN | Trask Coliseum · Wilmington, NC |
| 20 | Thu Jan 23 | atCharleston | W85-83 | 15-5 | .750 | - | | TD Arena · Charleston, SC |
| 21 | Sat Jan 25 | vsHampton | W83-62 | 16-5 | .762 | - | | Trask Coliseum · Wilmington, NC |
| 22 | Thu Jan 30 | atNC A&T | W83-59 | 17-5 | .773 | - | | Corbett Sports Center · Greensboro, NC |
| 23 | Sat Feb 1 | vsStony Brook | W80-70 | 18-5 | .783 | - | | Trask Coliseum · Wilmington, NC |
| 24 | Thu Feb 6 | atDelaware | W77-67 | 19-5 | .792 | - | | Bob Carpenter Center · Newark, DE |
| 25 | Sat Feb 8 | atDrexel | W81-79 (2OT) | 20-5 | .800 | - | CBSSN | Daskalakis Athletic Center · Philadelphia, PA |
| 26 | Thu Feb 13 | vsCharleston | W86-66 | 21-5 | .808 | - | CBSSN | Trask Coliseum · Wilmington, NC |
| 27 | Sat Feb 15 | vsElon | L70-81 | 21-6 | .778 | - | | Trask Coliseum · Wilmington, NC |
| 28 | Sat Feb 22 | atHampton | L70-83 | 21-7 | .750 | - | CBSSN | Convocation Center (VA) · Hampton, VA |
| 29 | Mon Feb 24 | atWilliam & Mary | W79-70 | 22-7 | .759 | - | | Kaplan Arena · Williamsburg, VA |
| 30 | Thu Feb 27 | atCampbell | W79-60 | 23-7 | .767 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 31 | Sat Mar 1 | vsDelaware | W88-58 | 24-7 | .774 | - | | Trask Coliseum · Wilmington, NC |
| 32 | Sun Mar 9 | vsHampton | W79-65 | 25-7 | .781 | - | | Trask Coliseum · Wilmington, NC |
| 33 | Mon Mar 10 | vsCharleston | W68-67 | 26-7 | .788 | - | CBSSN | Trask Coliseum · Wilmington, NC |
| 34 | Tue Mar 11 | vsDelaware | W76-72 | 27-7 | .794 | - | CBSSN | Trask Coliseum · Wilmington, NC |
| 35 | Thu Mar 20 | at#3Texas Tech | L72-82 | 27-8 | .771 | #14 | truTV | United Supermarkets Arena · Lubbock, TX |
