| 1 | Mon Nov 7 | at #1UNC | L56-69 | 0-1 | .000 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Fri Nov 11 | vs TBD | W104-55 | 1-1 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 3 | Tue Nov 15 | at Oklahoma | L53-74 | 1-2 | .333 | - | | Lloyd Noble Center · Norman, OK |
| 4 | Fri Nov 18 | at #25UConn | L50-86 | 1-3 | .250 | - | FS2 | Gampel Pavilion · Storrs, CT |
| 5 | Mon Nov 21 | vsTBD | W94-47 | 2-3 | .400 | - | | Trask Coliseum · Wilmington, NC |
| 6 | Fri Nov 25 | at Missouri St | W68-54 | 3-3 | .500 | - | | Great Southern Bank Arena · Springfield, MO |
| 7 | Sat Nov 26 | at Vermont | W68-66 | 4-3 | .571 | - | | Patrick Gymnasium · Burlington, VT |
| 8 | Sun Nov 27 | vs North Texas | W55-51 | 5-3 | .625 | - | | Trask Coliseum · Wilmington, NC |
| 9 | Wed Nov 30 | at Coast Car | W60-58 | 6-3 | .667 | - | | The HTC Center · Conway, SC |
| 10 | Tue Dec 6 | vs E Carolina | W74-61 | 7-3 | .700 | - | | Trask Coliseum · Wilmington, NC |
| 11 | Sat Dec 10 | vs Jacksonville | W81-53 | 8-3 | .727 | - | | Trask Coliseum · Wilmington, NC |
| 12 | Sun Dec 18 | vs High Point | W85-82 | 9-3 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 13 | Wed Dec 21 | at Campbell | W74-66 | 10-3 | .769 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 14 | Wed Dec 28 | at Monmouth | W68-55 | 11-3 | .786 | - | CBS | OceanFirst Bank Center · West Long Branch, NJ |
| 15 | Sat Dec 31 | vs Hampton | W82-65 | 12-3 | .800 | - | | Trask Coliseum · Wilmington, NC |
| 16 | Wed Jan 4 | at Elon | W81-66 | 13-3 | .813 | - | | Schar Center · Elon, NC |
| 17 | Sat Jan 7 | at NC A&T | W66-61 | 14-3 | .824 | - | | Corbett Sports Center · Greensboro, NC |
| 18 | Wed Jan 11 | vs #22Charleston | L69-71 | 14-4 | .778 | - | | Trask Coliseum · Wilmington, NC |
| 19 | Sat Jan 14 | vs William & Mary | L67-69 | 14-5 | .737 | - | CBS | Trask Coliseum · Wilmington, NC |
| 20 | Mon Jan 16 | vsElon | W62-54 | 15-5 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 21 | Thu Jan 19 | at Hofstra | L46-70 | 15-6 | .714 | - | CBS | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 22 | Sat Jan 21 | at Stony Brook | W62-51 | 16-6 | .727 | - | | Island FCU Arena · Stony Brook, NY |
| 23 | Thu Jan 26 | vsMonmouth | W52-49 | 17-6 | .739 | - | | Trask Coliseum · Wilmington, NC |
| 24 | Thu Feb 2 | vsNC A&T | W87-63 | 18-6 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 25 | Sat Feb 4 | atWilliam & Mary | W70-63 | 19-6 | .760 | - | | Kaplan Arena · Williamsburg, VA |
| 26 | Wed Feb 8 | atCharleston | L61-93 | 19-7 | .731 | - | | TD Arena · Charleston, SC |
| 27 | Sat Feb 11 | vs Northeastern | W71-59 | 20-7 | .741 | - | | Trask Coliseum · Wilmington, NC |
| 28 | Thu Feb 16 | at Drexel | W72-71 (2OT) | 21-7 | .750 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 29 | Sat Feb 18 | at Delaware | L66-75 | 21-8 | .724 | - | | Bob Carpenter Center · Newark, DE |
| 30 | Thu Feb 23 | vsStony Brook | W76-69 | 22-8 | .733 | - | | Trask Coliseum · Wilmington, NC |
| 31 | Sat Feb 25 | vs Towson | L53-57 | 22-9 | .710 | - | | Trask Coliseum · Wilmington, NC |
| 32 | Sun Mar 5 | vsDrexel | W73-68 | 23-9 | .719 | - | | Trask Coliseum · Wilmington, NC |
| 33 | Mon Mar 6 | atHofstra | W79-73 (OT) | 24-9 | .727 | - | CBS | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 34 | Tue Mar 7 | atCharleston | L58-63 | 24-10 | .706 | - | CBS | TD Arena · Charleston, SC |
