| 1 | Tue Nov 9 | at Illinois St | L63-68 | 0-1 | .000 | - | | Redbird Arena · Normal, IL |
| 2 | Fri Nov 12 | vs TBD | W77-68 | 1-1 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 3 | Tue Nov 16 | at Pitt | L51-59 | 1-2 | .333 | - | | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 18 | vs Coast Car | W65-53 | 2-2 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 5 | Sat Nov 20 | at Delaware St | W67-63 | 3-2 | .600 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 6 | Wed Nov 24 | vs Southern Miss | L66-80 | 3-3 | .500 | - | | Trask Coliseum · Wilmington, NC |
| 9 | Wed Dec 1 | vs Norfolk St | L69-74 | 3-4 | .429 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Sat Dec 11 | at Jacksonville | L48-77 | 3-5 | .375 | - | | Swisher Gymnasium · Jacksonville, FL |
| 11 | Wed Dec 15 | vsTBD | W85-55 | 4-5 | .444 | - | | Trask Coliseum · Wilmington, NC |
| 12 | Sat Dec 18 | at High Point | W71-69 (OT) | 5-5 | .500 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 13 | Wed Dec 22 | vs Campbell | W65-58 | 6-5 | .545 | - | | Trask Coliseum · Wilmington, NC |
| 14 | Wed Dec 29 | vs Delaware | W70-68 | 7-5 | .583 | - | | Trask Coliseum · Wilmington, NC |
| 15 | Fri Dec 31 | vs Drexel | PPD | 27-9 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 16 | Mon Jan 3 | at Hofstra | PPD | 27-9 | .750 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 17 | Wed Jan 5 | at Northeastern | PPD | 27-9 | .750 | - | | Matthews Arena · Boston, MA |
| 18 | Sun Jan 9 | vs William & Mary | PPD | 27-9 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 19 | Wed Jan 12 | vs Elon | W73-66 | 8-5 | .615 | - | | Trask Coliseum · Wilmington, NC |
| 20 | Mon Jan 17 | at Charleston | W86-78 | 9-5 | .643 | - | | TD Arena · Charleston, SC |
| 21 | Thu Jan 20 | at JMU | W71-70 | 10-5 | .667 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 22 | Sat Jan 22 | at Towson | W81-77 (OT) | 11-5 | .688 | - | | SECU Arena · Towson, MD |
| 23 | Mon Jan 24 | atNortheastern | W74-68 | 12-5 | .706 | - | | Matthews Arena · Boston, MA |
| 24 | Thu Jan 27 | vsNortheastern | W67-62 | 13-5 | .722 | - | | Trask Coliseum · Wilmington, NC |
| 25 | Sat Jan 29 | vsHofstra | W78-72 | 14-5 | .737 | - | | Trask Coliseum · Wilmington, NC |
| 26 | Mon Jan 31 | vsDrexel | W70-63 | 15-5 | .750 | - | | Trask Coliseum · Wilmington, NC |
| 27 | Thu Feb 3 | atElon | L65-78 | 15-6 | .714 | - | | Schar Center · Elon, NC |
| 28 | Sat Feb 5 | atWilliam & Mary | W92-70 | 16-6 | .727 | - | CBS | Kaplan Arena · Williamsburg, VA |
| 29 | Mon Feb 7 | atHofstra | L71-73 | 16-7 | .696 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 30 | Sat Feb 12 | vsCharleston | W85-79 | 17-7 | .708 | - | | Trask Coliseum · Wilmington, NC |
| 31 | Mon Feb 14 | vsWilliam & Mary | W80-73 (OT) | 18-7 | .720 | - | | Trask Coliseum · Wilmington, NC |
| 32 | Thu Feb 17 | vsTowson | L55-79 | 18-8 | .692 | - | CBS | Trask Coliseum · Wilmington, NC |
| 33 | Sat Feb 19 | vsJMU | W78-77 (OT) | 19-8 | .704 | - | | Trask Coliseum · Wilmington, NC |
| 34 | Thu Feb 24 | atDrexel | W69-63 | 20-8 | .714 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 35 | Sat Feb 26 | atDelaware | W69-62 | 21-8 | .724 | - | | Bob Carpenter Center · Newark, DE |
| 36 | Sun Mar 6 | vsElon | W75-58 | 22-8 | .733 | - | | Trask Coliseum · Wilmington, NC |
| 37 | Mon Mar 7 | vsCharleston | W60-57 | 23-8 | .742 | - | CBS | Trask Coliseum · Wilmington, NC |
| 38 | Tue Mar 8 | vsDelaware | L55-59 | 23-9 | .719 | - | CBS | Trask Coliseum · Wilmington, NC |
| 39 | Sun Mar 20 | vs VMI | W93-78 | 24-9 | .727 | - | | Trask Coliseum · Wilmington, NC |
| 40 | Mon Mar 21 | vs Drake | W76-75 | 25-9 | .735 | - | | Trask Coliseum · Wilmington, NC |
| 41 | Tue Mar 22 | at N Colorado | W80-64 | 26-9 | .743 | - | ESPN2 | Bank of Colorado Arena · Greeley, CO |
| 42 | Wed Mar 23 | vs MTSU | W96-90 (2OT) | 27-9 | .750 | - | ESPN2 | Trask Coliseum · Wilmington, NC |
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