| 1 | Mon Nov 7 | vs Fairfield | W71-59 | 1-0 | 1.000 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 2 | Fri Nov 11 | vs Georgia | W81-71 | 2-0 | 1.000 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Tue Nov 15 | vs Utah Valley | W68-65 (OT) | 3-0 | 1.000 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 4 | Fri Nov 18 | vs La Salle | W75-63 | 4-0 | 1.000 | - | CBS | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Sun Nov 20 | at LMU | L75-77 (OT) | 4-1 | .800 | - | | Gersten Pavilion · Los Angeles, CA |
| 6 | Wed Nov 23 | vs SC State | W105-74 | 5-1 | .833 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Sat Nov 26 | vs Hampton | W97-70 | 6-1 | .857 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 8 | Tue Nov 29 | at Wisconsin | W78-75 | 7-1 | .875 | - | ESPNU | Kohl Center · Madison, WI |
| 9 | Fri Dec 2 | at Clemson | L57-77 | 7-2 | .778 | - | | Littlejohn Coliseum · Clemson, SC |
| 10 | Sat Dec 10 | at LSU | L70-72 | 7-3 | .700 | - | ESPNU | Pete Maravich Assembly Center · Baton Rouge, LA |
| 11 | Wed Dec 14 | vs Appalachian St | W67-66 | 8-3 | .727 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 12 | Sat Dec 17 | at Rutgers | L57-81 | 8-4 | .667 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 13 | Tue Dec 20 | vs #14Duke | W81-70 | 9-4 | .692 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 14 | Sat Dec 31 | vs Virginia Tech | W77-75 | 10-4 | .714 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Wed Jan 4 | at UNC | L79-88 | 10-5 | .667 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Sat Jan 7 | at Louisville | W80-72 | 11-5 | .688 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 17 | Wed Jan 11 | vs Florida St | W90-75 | 12-5 | .706 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Sat Jan 14 | at Boston College | W85-63 | 13-5 | .722 | - | ESPN2 | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Tue Jan 17 | vs#19Clemson | W87-77 | 14-5 | .737 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Sat Jan 21 | vs #10Virginia | L67-76 | 14-6 | .700 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 21 | Wed Jan 25 | at Pitt | L79-81 | 14-7 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 28 | vs NC State | L77-79 | 14-8 | .636 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Tue Jan 31 | atDuke | L73-75 | 14-9 | .609 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 24 | Sat Feb 4 | at Notre Dame | W81-64 | 15-9 | .625 | - | | Purcell Pavilion · South Bend, IN |
| 25 | Tue Feb 7 | vsUNC | W92-85 | 16-9 | .640 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 26 | Sat Feb 11 | vs Georgia Tech | W71-70 | 17-9 | .654 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 27 | Sat Feb 18 | at #15Miami | L87-96 | 17-10 | .630 | - | | Watsco Center · Coral Gables, FL |
| 28 | Wed Feb 22 | atNC State | L74-90 | 17-11 | .607 | - | | PNC Arena · Raleigh, NC |
| 29 | Sat Feb 25 | vsNotre Dame | W66-58 | 18-11 | .621 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 30 | Tue Feb 28 | vsBoston College | L69-71 | 18-12 | .600 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 31 | Sat Mar 4 | at Syracuse | L63-72 | 18-13 | .581 | - | ERADM | JMA Wireless Dome · Syracuse, NY |
| 32 | Wed Mar 8 | atSyracuse | W77-74 | 19-13 | .594 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 33 | Thu Mar 9 | atMiami | L72-74 | 19-14 | .576 | - | ESPN2 | Watsco Center · Coral Gables, FL |
