| 1 | Wed Nov 6 | at Boston College | L70-77 | 0-1 | .000 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Sun Nov 10 | vsColumbia | W65-63 | 1-1 | .500 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Wed Nov 13 | vsUNC Asheville | W98-79 | 2-1 | .667 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 4 | Sun Nov 17 | atCharlotte | L65-67 (OT) | 2-2 | .500 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 5 | Fri Nov 22 | atDavidson | W82-70 | 3-2 | .600 | - | | John M. Belk Arena · Davidson, NC |
| 6 | Thu Nov 28 | atCharleston | W65-56 | 4-2 | .667 | - | ESPNEWS | TD Arena · Charleston, SC |
| 7 | Fri Nov 29 | vsLong Beach St | W88-75 | 5-2 | .714 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 8 | Sun Dec 1 | atArizona | L66-73 | 5-3 | .625 | - | ESPN | McKale Center · Tucson, AZ |
| 9 | Wed Dec 4 | atPenn State | L54-76 | 5-4 | .556 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 10 | Sat Dec 7 | vsNC State | L82-91 | 5-5 | .500 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 11 | Sat Dec 14 | vsXavier | W80-78 | 6-5 | .545 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 12 | Sat Dec 21 | vsNC A&T | W76-64 | 7-5 | .583 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 13 | Sat Jan 4 | atPitt | W69-65 | 8-5 | .615 | - | | Petersen Events Center · Pittsburgh, PA |
| 14 | Wed Jan 8 | vs#10Florida St | L68-78 | 8-6 | .571 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Sat Jan 11 | at#2Duke | L59-90 | 8-7 | .533 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 16 | Tue Jan 14 | vsVirginia Tech | L70-80 | 8-8 | .500 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 17 | Sun Jan 19 | vsBoston College | W80-62 | 9-8 | .529 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Tue Jan 21 | atClemson | L68-71 | 9-9 | .500 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 19 | Sun Jan 26 | vsVirginia | L63-65 (OT) | 9-10 | .474 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Wed Jan 29 | atNotre Dame | L80-90 | 9-11 | .450 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 21 | Sat Feb 1 | vsClemson | W56-44 | 10-11 | .476 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 22 | Wed Feb 5 | at#5Louisville | L76-86 | 10-12 | .455 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 23 | Sat Feb 8 | atSyracuse | L73-75 | 10-13 | .435 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 24 | Tue Feb 11 | vsUNC | W74-57 | 11-13 | .458 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 25 | Sat Feb 15 | atMiami | L54-71 | 11-14 | .440 | - | | Watsco Center · Coral Gables, FL |
| 26 | Wed Feb 19 | vsGeorgia Tech | L79-86 | 11-15 | .423 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 27 | Tue Feb 25 | vs#7Duke | W113-101 (2OT) | 12-15 | .444 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 28 | Sat Feb 29 | vsNotre Dame | W84-73 | 13-15 | .464 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Tue Mar 3 | atUNC | L83-93 | 13-16 | .448 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Fri Mar 6 | atNC State | L64-84 | 13-17 | .433 | - | ACC Network | PNC Arena · Raleigh, NC |
| 31 | Tue Mar 10 | vsPitt | L72-81 | 13-18 | .419 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
