| 1 | Mon Nov 3 | vs American | 8:00 PM | 22-13 | .629 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 2 | Fri Nov 7 | vsMorehead St | 7:00 PM | 15-17 | .469 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Tue Nov 11 | at#7Michigan | TBD | 27-10 | .730 | - | | Crisler Center · Ann Arbor, MI |
| 4 | Sun Nov 16 | vsUMass Lowell | 2:00 PM | 17-15 | .531 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Thu Nov 20 | at#10Texas Tech | 8:30 PM | 28-9 | .757 | - | CBS | United Supermarkets Arena · Lubbock, TX |
| 6 | Tue Nov 25 | vsCampbell | 7:00 PM | 15-17 | .469 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Fri Nov 28 | vsNortheastern | 12:00 PM | 17-15 | .531 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 8 | Tue Dec 2 | vsOklahoma | 7:00 PM | 20-14 | .588 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 9 | Sat Dec 6 | atWest Virginia | 6:00 PM | 19-13 | .594 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 10 | Sun Dec 14 | vsQueens | TBD | 20-15 | .571 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 11 | Wed Dec 17 | vsLongwood | TBD | 18-14 | .563 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 12 | Sun Dec 21 | vsVanderbilt | TBD | 20-13 | .606 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 13 | Wed Dec 31 | atNC State | 12:00 PM | 12-19 | .387 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 14 | Sat Jan 3 | vsVirginia Tech | 12:00 PM | 13-19 | .406 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Wed Jan 7 | vsMiami | 7:00 PM | 7-24 | .226 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 16 | Sat Jan 10 | at#25UNC | 6:00 PM | 23-14 | .622 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Sat Jan 17 | atFlorida St | TBD | 17-15 | .531 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Tue Jan 20 | vsSMU | 9:00 PM | 24-11 | .686 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 19 | Sat Jan 24 | at#6Duke | TBD | 35-4 | .897 | - | | Cameron Indoor Stadium · Durham, NC |
| 20 | Tue Jan 27 | atPitt | 6:00 PM | 17-15 | .531 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 21 | Sat Jan 31 | vsNC State | TBD | 12-19 | .387 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 22 | Sat Feb 7 | vs#11Louisville | 12:00 PM | 27-8 | .771 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Wed Feb 11 | atGeorgia Tech | 9:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 24 | Sat Feb 14 | vsStanford | 4:00 PM | 21-14 | .600 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 25 | Wed Feb 18 | vsClemson | 7:00 PM | 27-7 | .794 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 26 | Sat Feb 21 | atVirginia Tech | 12:00 PM | 13-19 | .406 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 27 | Tue Feb 24 | atBoston College | 7:00 PM | 12-19 | .387 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 28 | Sat Feb 28 | vsSyracuse | TBD | 14-19 | .424 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Tue Mar 3 | atVirginia | 7:00 PM | 15-17 | .469 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 30 | Sat Mar 7 | vsCalifornia | 4:00 PM | 14-19 | .424 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
