| 1 | Mon Nov 4 | vs Coppin St | W64-49 | 1-0 | 1.000 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 2 | Thu Nov 7 | vsNC A&T | W80-64 | 2-0 | 1.000 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Sun Nov 10 | vsMichigan | W72-70 | 3-0 | 1.000 | - | ESPN2 | Greensboro Coliseum · Greensboro, NC |
| 4 | Wed Nov 13 | vsSC Upstate | W85-80 | 4-0 | 1.000 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Sat Nov 16 | atXavier | L60-75 | 4-1 | .800 | - | FS1 | Cintas Center · Cincinnati, OH |
| 6 | Tue Nov 19 | vsW Carolina | W82-69 | 5-1 | .833 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Sat Nov 23 | vsDetroit Mercy | W67-57 | 6-1 | .857 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 8 | Thu Nov 28 | vs#18Florida | L58-75 | 6-2 | .750 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 9 | Fri Nov 29 | vsMinnesota | W57-51 | 7-2 | .778 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 10 | Tue Dec 3 | at#22Texas A&M | L44-57 | 7-3 | .700 | - | ESPN2 | Reed Arena · College Station, TX |
| 11 | Sat Dec 7 | vsBoston College | W72-66 | 8-3 | .727 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 12 | Tue Dec 17 | vsJMU | W75-58 | 9-3 | .750 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 13 | Sat Dec 21 | at#25Clemson | L62-73 | 9-4 | .692 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 14 | Tue Dec 31 | atSyracuse | W81-71 | 10-4 | .714 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 15 | Sat Jan 4 | vsNC State | W77-59 | 11-4 | .733 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 16 | Sat Jan 11 | atMiami | W88-78 | 12-4 | .750 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 17 | Wed Jan 15 | vsStanford | W80-67 | 13-4 | .765 | - | ESPNEWS | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Sat Jan 18 | atVirginia Tech | W72-63 | 14-4 | .778 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Tue Jan 21 | vsUNC | W67-66 | 15-4 | .789 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Sat Jan 25 | vs#2Duke | L56-63 | 15-5 | .750 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 21 | Tue Jan 28 | at#21Louisville | L59-72 | 15-6 | .714 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 22 | Sat Feb 1 | vsPitt | W76-74 | 16-6 | .727 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Wed Feb 5 | atStanford | W79-73 | 17-6 | .739 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 24 | Sat Feb 8 | atCalifornia | W76-66 | 18-6 | .750 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 25 | Wed Feb 12 | vsFlorida St | L70-72 | 18-7 | .720 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 26 | Sat Feb 15 | atSMU | W77-66 | 19-7 | .731 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 27 | Sat Feb 22 | atNC State | L73-85 | 19-8 | .704 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 28 | Wed Feb 26 | vsVirginia | L75-83 | 19-9 | .679 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Sat Mar 1 | vsNotre Dame | W74-71 | 20-9 | .690 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 30 | Mon Mar 3 | at#2Duke | L60-93 | 20-10 | .667 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Sat Mar 8 | vsGeorgia Tech | W69-43 | 21-10 | .677 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 32 | Thu Mar 13 | vsUNC | L59-68 | 21-11 | .656 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
