| 71 | Tue Jun 16 | at Yankees | 7:05 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 72 | Wed Jun 17 | at Yankees | 7:05 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 73 | Thu Jun 18 | at Yankees | 7:05 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 74 | Fri Jun 19 | at Tigers | 6:40 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 75 | Sat Jun 20 | at Tigers | 1:10 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 76 | Sun Jun 21 | at Tigers | 1:40 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 77 | Mon Jun 22 | vs Guardians | 7:40 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 78 | Tue Jun 23 | vs Guardians | 7:40 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 79 | Wed Jun 24 | vs Guardians | 2:10 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 80 | Fri Jun 26 | vs Royals | 7:40 PM | 29-44 | .397 | Guaranteed Rate Field · Chicago, IL |
| 81 | Sat Jun 27 | vs Royals | 4:10 PM | 29-44 | .397 | Guaranteed Rate Field · Chicago, IL |
| 82 | Sun Jun 28 | vs Royals | 2:10 PM | 29-44 | .397 | Guaranteed Rate Field · Chicago, IL |
| 83 | Mon Jun 29 | at Orioles | 6:35 PM | 34-39 | .466 | Camden Yards · Baltimore, MD |
| 84 | Tue Jun 30 | at Orioles | 6:35 PM | 34-39 | .466 | Camden Yards · Baltimore, MD |
| 85 | Wed Jul 1 | at Orioles | 12:35 PM | 34-39 | .466 | Camden Yards · Baltimore, MD |
| 86 | Thu Jul 2 | at Guardians | 6:40 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 87 | Fri Jul 3 | at Guardians | 7:10 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 88 | Sat Jul 4 | at Guardians | 7:10 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 89 | Sun Jul 5 | at Guardians | 2:00 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 90 | Tue Jul 7 | vs Red Sox | 7:40 PM | 29-40 | .420 | Guaranteed Rate Field · Chicago, IL |
| 91 | Wed Jul 8 | vs Red Sox | 7:40 PM | 29-40 | .420 | Guaranteed Rate Field · Chicago, IL |
| 92 | Thu Jul 9 | vs Red Sox | 2:10 PM | 29-40 | .420 | Guaranteed Rate Field · Chicago, IL |
| 93 | Fri Jul 10 | vs Athletics | 7:40 PM | 36-36 | .500 | Guaranteed Rate Field · Chicago, IL |
| 94 | Sat Jul 11 | vs Athletics | 2:10 PM | 36-36 | .500 | Guaranteed Rate Field · Chicago, IL |
| 95 | Sun Jul 12 | vs Athletics | 2:10 PM | 36-36 | .500 | Guaranteed Rate Field · Chicago, IL |
| 96 | Fri Jul 17 | at Blue Jays | 7:15 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 97 | Sat Jul 18 | at Blue Jays | 3:07 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 98 | Sun Jul 19 | at Blue Jays | 12:15 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 99 | Mon Jul 20 | at Rangers | 8:05 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 100 | Tue Jul 21 | at Rangers | 8:05 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 101 | Wed Jul 22 | at Rangers | 8:05 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 102 | Fri Jul 24 | vs Astros | 7:40 PM | 33-41 | .446 | Guaranteed Rate Field · Chicago, IL |
| 103 | Sat Jul 25 | vs Astros | 7:10 PM | 33-41 | .446 | Guaranteed Rate Field · Chicago, IL |
| 104 | Sun Jul 26 | vs Astros | 2:10 PM | 33-41 | .446 | Guaranteed Rate Field · Chicago, IL |
| 105 | Mon Jul 27 | vs Yankees | 7:40 PM | 43-27 | .614 | Guaranteed Rate Field · Chicago, IL |
| 106 | Tue Jul 28 | vs Yankees | 7:40 PM | 43-27 | .614 | Guaranteed Rate Field · Chicago, IL |
| 107 | Wed Jul 29 | vs Yankees | 7:40 PM | 43-27 | .614 | Guaranteed Rate Field · Chicago, IL |
| 108 | Thu Jul 30 | vs Yankees | 2:10 PM | 43-27 | .614 | Guaranteed Rate Field · Chicago, IL |
| 109 | Fri Jul 31 | at Rays | 7:10 PM | 41-28 | .594 | Tropicana Field · St. Petersburg, FL |
| 110 | Sat Aug 1 | at Rays | 4:10 PM | 41-28 | .594 | Tropicana Field · St. Petersburg, FL |
| 111 | Sun Aug 2 | at Rays | 1:40 PM | 41-28 | .594 | Tropicana Field · St. Petersburg, FL |
| 112 | Tue Aug 4 | at Red Sox | 7:10 PM | 29-40 | .420 | Fenway Park · Boston, MA |
| 113 | Wed Aug 5 | at Red Sox | 7:10 PM | 29-40 | .420 | Fenway Park · Boston, MA |
| 114 | Thu Aug 6 | at Red Sox | 7:10 PM | 29-40 | .420 | Fenway Park · Boston, MA |
| 115 | Fri Aug 7 | vs Guardians | 7:40 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sat Aug 8 | vs Guardians | 7:15 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 117 | Sun Aug 9 | vs Guardians | 2:10 PM | 39-33 | .542 | Guaranteed Rate Field · Chicago, IL |
| 118 | Tue Aug 11 | vs Reds | 7:40 PM | 34-37 | .479 | Guaranteed Rate Field · Chicago, IL |
| 119 | Wed Aug 12 | vs Reds | 7:40 PM | 34-37 | .479 | Guaranteed Rate Field · Chicago, IL |
| 120 | Thu Aug 13 | vs Reds | 2:10 PM | 34-37 | .479 | Guaranteed Rate Field · Chicago, IL |
| 121 | Fri Aug 14 | at Tigers | 6:40 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 122 | Sat Aug 15 | at Tigers | 1:10 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 123 | Sun Aug 16 | at Tigers | 1:40 PM | 30-42 | .417 | Comerica Park · Detroit, MI |
| 124 | Mon Aug 17 | at Cubs | 8:05 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 125 | Tue Aug 18 | at Cubs | 8:05 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 126 | Wed Aug 19 | at Cubs | 2:20 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 127 | Thu Aug 20 | vs Braves | 2:10 PM | 46-25 | .648 | Guaranteed Rate Field · Chicago, IL |
| 128 | Fri Aug 21 | vs Mets | 7:40 PM | 32-40 | .444 | Guaranteed Rate Field · Chicago, IL |
| 129 | Sat Aug 22 | vs Mets | 7:10 PM | 32-40 | .444 | Guaranteed Rate Field · Chicago, IL |
| 130 | Sun Aug 23 | vs Mets | 2:10 PM | 32-40 | .444 | Guaranteed Rate Field · Chicago, IL |
| 131 | Mon Aug 24 | vs Rangers | 7:40 PM | 35-37 | .486 | Guaranteed Rate Field · Chicago, IL |
| 132 | Tue Aug 25 | vs Rangers | 7:40 PM | 35-37 | .486 | Guaranteed Rate Field · Chicago, IL |
| 133 | Wed Aug 26 | vs Rangers | 7:40 PM | 35-37 | .486 | Guaranteed Rate Field · Chicago, IL |
| 134 | Fri Aug 28 | at Twins | 8:10 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 135 | Sat Aug 29 | at Twins | 2:10 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 136 | Sun Aug 30 | at Twins | 2:10 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 137 | Mon Aug 31 | at Astros | 8:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 138 | Tue Sep 1 | at Astros | 8:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 139 | Wed Sep 2 | at Astros | 8:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 140 | Thu Sep 3 | at Astros | 2:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 141 | Fri Sep 4 | vs Twins | 7:40 PM | 34-40 | .459 | Guaranteed Rate Field · Chicago, IL |
| 142 | Sat Sep 5 | vs Twins | 7:10 PM | 34-40 | .459 | Guaranteed Rate Field · Chicago, IL |
| 143 | Sun Sep 6 | vs Twins | 2:10 PM | 34-40 | .459 | Guaranteed Rate Field · Chicago, IL |
| 144 | Tue Sep 8 | vs Pirates | 7:40 PM | 36-37 | .493 | Guaranteed Rate Field · Chicago, IL |
| 145 | Wed Sep 9 | vs Pirates | 7:40 PM | 36-37 | .493 | Guaranteed Rate Field · Chicago, IL |
| 146 | Thu Sep 10 | vs Pirates | 7:40 PM | 36-37 | .493 | Guaranteed Rate Field · Chicago, IL |
| 147 | Fri Sep 11 | at Cardinals | 8:15 PM | 39-31 | .557 | Busch Stadium · St. Louis, MO |
| 148 | Sat Sep 12 | at Cardinals | 7:15 PM | 39-31 | .557 | Busch Stadium · St. Louis, MO |
| 149 | Sun Sep 13 | at Cardinals | 2:15 PM | 39-31 | .557 | Busch Stadium · St. Louis, MO |
| 150 | Mon Sep 14 | at Guardians | 6:40 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 151 | Tue Sep 15 | at Guardians | 6:40 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 152 | Wed Sep 16 | at Guardians | 1:10 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 153 | Thu Sep 17 | vs Tigers | 7:40 PM | 30-42 | .417 | Guaranteed Rate Field · Chicago, IL |
| 154 | Fri Sep 18 | vs Tigers | 7:40 PM | 30-42 | .417 | Guaranteed Rate Field · Chicago, IL |
| 155 | Sat Sep 19 | vs Tigers | 7:10 PM | 30-42 | .417 | Guaranteed Rate Field · Chicago, IL |
| 156 | Sun Sep 20 | vs Tigers | 2:10 PM | 30-42 | .417 | Guaranteed Rate Field · Chicago, IL |
| 157 | Tue Sep 22 | at Royals | 7:40 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 158 | Wed Sep 23 | at Royals | 7:40 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 159 | Thu Sep 24 | at Royals | 2:10 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 160 | Fri Sep 25 | vs Rockies | 7:40 PM | 27-46 | .370 | Guaranteed Rate Field · Chicago, IL |
| 161 | Sat Sep 26 | vs Rockies | 7:10 PM | 27-46 | .370 | Guaranteed Rate Field · Chicago, IL |
| 162 | Sun Sep 27 | vs Rockies | 3:10 PM | 27-46 | .370 | Guaranteed Rate Field · Chicago, IL |