| 1 | Thu Mar 26 | at Brewers | L2-14 | 0-1 | .000 | American Family Field · Milwaukee, WI |
| 2 | Sat Mar 28 | at Brewers | L1-6 | 0-2 | .000 | American Family Field · Milwaukee, WI |
| 3 | Sun Mar 29 | at Brewers | L7-9 | 0-3 | .000 | American Family Field · Milwaukee, WI |
| 4 | Mon Mar 30 | at Marlins | W9-4 | 1-3 | .250 | LoanDepot Park · Miami, FL |
| 5 | Tue Mar 31 | at Marlins | L2-9 | 1-4 | .200 | LoanDepot Park · Miami, FL |
| 6 | Wed Apr 1 | at Marlins | L0-10 | 1-5 | .167 | LoanDepot Park · Miami, FL |
| 7 | Fri Apr 3 | vs Blue Jays | W5-4 (10) | 2-5 | .286 | Guaranteed Rate Field · Chicago, IL |
| 8 | Sat Apr 4 | vs Blue Jays | W6-3 | 3-5 | .375 | Guaranteed Rate Field · Chicago, IL |
| 9 | Sun Apr 5 | vs Blue Jays | W3-0 | 4-5 | .444 | Guaranteed Rate Field · Chicago, IL |
| 10 | Mon Apr 6 | vs Orioles | L1-2 | 4-6 | .400 | Guaranteed Rate Field · Chicago, IL |
| 11 | Tue Apr 7 | vs Orioles | L2-4 | 4-7 | .364 | Guaranteed Rate Field · Chicago, IL |
| 12 | Wed Apr 8 | vs Orioles | L3-5 | 4-8 | .333 | Guaranteed Rate Field · Chicago, IL |
| 13 | Thu Apr 9 | at Royals | W2-0 | 5-8 | .385 | Kauffman Stadium · Kansas City, MO |
| 14 | Fri Apr 10 | at Royals | L0-2 | 5-9 | .357 | Kauffman Stadium · Kansas City, MO |
| 15 | Sat Apr 11 | at Royals | L0-2 | 5-10 | .333 | Kauffman Stadium · Kansas City, MO |
| 16 | Sun Apr 12 | at Royals | W6-5 | 6-10 | .375 | Kauffman Stadium · Kansas City, MO |
| 17 | Tue Apr 14 | vs Rays | L5-8 | 6-11 | .353 | Guaranteed Rate Field · Chicago, IL |
| 18 | Wed Apr 15 | vs Rays | L3-8 | 6-12 | .333 | Guaranteed Rate Field · Chicago, IL |
| 19 | Thu Apr 16 | vs Rays | L3-5 | 6-13 | .316 | Guaranteed Rate Field · Chicago, IL |
| 20 | Fri Apr 17 | at Athletics | W9-2 | 7-13 | .350 | Sutter Health Park · West Sacramento, CA |
| 21 | Sat Apr 18 | at Athletics | L6-7 (11) | 7-14 | .333 | Sutter Health Park · West Sacramento, CA |
| 22 | Sun Apr 19 | at Athletics | W7-4 | 8-14 | .364 | Sutter Health Park · West Sacramento, CA |
| 23 | Tue Apr 21 | at D-backs | W11-5 | 9-14 | .391 | Chase Field · Phoenix, AZ |
| 24 | Wed Apr 22 | at D-backs | L7-11 | 9-15 | .375 | Chase Field · Phoenix, AZ |
| 25 | Thu Apr 23 | at D-backs | W4-1 | 10-15 | .400 | Chase Field · Phoenix, AZ |
| 26 | Fri Apr 24 | vs Nationals | W5-4 | 11-15 | .423 | Guaranteed Rate Field · Chicago, IL |
| 27 | Sat Apr 25 | vs Nationals | L3-6 (10) | 11-16 | .407 | Guaranteed Rate Field · Chicago, IL |
| 28 | Sun Apr 26 | vs Nationals | L1-2 (10) | 11-17 | .393 | Guaranteed Rate Field · Chicago, IL |
| 29 | Mon Apr 27 | vs Angels | W8-7 | 12-17 | .414 | Guaranteed Rate Field · Chicago, IL |
| 30 | Tue Apr 28 | vs Angels | W5-2 | 13-17 | .433 | Guaranteed Rate Field · Chicago, IL |
| 31 | Wed Apr 29 | vs Angels | W3-2 (10) | 14-17 | .452 | Guaranteed Rate Field · Chicago, IL |
| 32 | Fri May 1 | at Padres | W8-2 | 15-17 | .469 | Petco Park · San Diego, CA |
| 33 | Sat May 2 | at Padres | W4-0 | 16-17 | .485 | Petco Park · San Diego, CA |
| 34 | Sun May 3 | at Padres | L3-4 | 16-18 | .471 | Petco Park · San Diego, CA |
| 35 | Mon May 4 | at Angels | W6-0 | 17-18 | .486 | Angel Stadium · Anaheim, CA |
| 36 | Tue May 5 | at Angels | L3-4 | 17-19 | .472 | Angel Stadium · Anaheim, CA |
| 37 | Wed May 6 | at Angels | L2-8 | 17-20 | .459 | Angel Stadium · Anaheim, CA |
| 38 | Fri May 8 | vs Mariners | L8-12 | 17-21 | .447 | Guaranteed Rate Field · Chicago, IL |
| 39 | Sat May 9 | vs Mariners | W6-1 | 18-21 | .462 | Guaranteed Rate Field · Chicago, IL |
| 40 | Sun May 10 | vs Mariners | W2-1 | 19-21 | .475 | Guaranteed Rate Field · Chicago, IL |
| 41 | Tue May 12 | vs Royals | W6-5 | 20-21 | .488 | Guaranteed Rate Field · Chicago, IL |
| 42 | Wed May 13 | vs Royals | W6-5 | 21-21 | .500 | Guaranteed Rate Field · Chicago, IL |
| 43 | Thu May 14 | vs Royals | W6-2 | 22-21 | .512 | Guaranteed Rate Field · Chicago, IL |
| 44 | Fri May 15 | vs Cubs | L5-10 | 22-22 | .500 | Guaranteed Rate Field · Chicago, IL |
| 45 | Sat May 16 | vs Cubs | W8-3 | 23-22 | .511 | Guaranteed Rate Field · Chicago, IL |
| 46 | Sun May 17 | vs Cubs | W9-8 (10) | 24-22 | .522 | Guaranteed Rate Field · Chicago, IL |
| 47 | Mon May 18 | at Mariners | L1-6 | 24-23 | .511 | T-Mobile Park · Seattle, WA |
| 48 | Tue May 19 | at Mariners | W2-1 | 25-23 | .521 | T-Mobile Park · Seattle, WA |
| 49 | Wed May 20 | at Mariners | L4-5 | 25-24 | .510 | T-Mobile Park · Seattle, WA |
| 50 | Fri May 22 | at Giants | W9-4 | 26-24 | .520 | Oracle Park · San Francisco, CA |
| 51 | Sat May 23 | at Giants | L3-10 | 26-25 | .510 | Oracle Park · San Francisco, CA |
| 52 | Sun May 24 | at Giants | L5-8 | 26-26 | .500 | Oracle Park · San Francisco, CA |
| 53 | Mon May 25 | vs Twins | W3-1 | 27-26 | .509 | Guaranteed Rate Field · Chicago, IL |
| 54 | Tue May 26 | vs Twins | L3-5 (11) | 27-27 | .500 | Guaranteed Rate Field · Chicago, IL |
| 55 | Wed May 27 | vs Twins | W15-2 | 28-27 | .509 | Guaranteed Rate Field · Chicago, IL |
| 56 | Thu May 28 | vs Twins | W6-2 | 29-27 | .518 | Guaranteed Rate Field · Chicago, IL |
| 57 | Fri May 29 | vs Tigers | W4-3 (10) | 30-27 | .526 | Guaranteed Rate Field · Chicago, IL |
| 58 | Sat May 30 | vs Tigers | W7-1 | 31-27 | .534 | Guaranteed Rate Field · Chicago, IL |
| 59 | Sun May 31 | vs Tigers | W2-1 | 32-27 | .542 | Guaranteed Rate Field · Chicago, IL |
| 60 | Mon Jun 1 | at Twins | L6-9 | 32-28 | .533 | Target Field · Minneapolis, MN |
| 61 | Tue Jun 2 | at Twins | L4-6 | 32-29 | .525 | Target Field · Minneapolis, MN |
| 62 | Wed Jun 3 | at Twins | W8-0 | 33-29 | .532 | Target Field · Minneapolis, MN |
| 63 | Fri Jun 5 | at Phillies | L6-8 | 33-30 | .524 | Citizens Bank Park · Philadelphi, PA |
| 64 | Sat Jun 6 | at Phillies | W6-3 | 34-30 | .531 | Citizens Bank Park · Philadelphi, PA |
| 65 | Sun Jun 7 | at Phillies | L5-9 | 34-31 | .523 | Citizens Bank Park · Philadelphi, PA |
| 66 | Tue Jun 9 | vs Braves | W6-5 (10) | 35-31 | .530 | Guaranteed Rate Field · Chicago, IL |
| 67 | Wed Jun 10 | vs Braves | W2-1 | 36-31 | .537 | Guaranteed Rate Field · Chicago, IL |
| 68 | Fri Jun 12 | vs Dodgers | W8-2 | 37-31 | .544 | Guaranteed Rate Field · Chicago, IL |
| 69 | Sat Jun 13 | vs Dodgers | L1-7 | 37-32 | .536 | Guaranteed Rate Field · Chicago, IL |
| 70 | Sun Jun 14 | vs Dodgers | W6-4 | 38-32 | .543 | Guaranteed Rate Field · Chicago, IL |
| 71 | Tue Jun 16 | at Yankees | L2-12 | 38-33 | .535 | Yankee Stadium · The Bronx, NY |
| 72 | Wed Jun 17 | at Yankees | L5-10 | 38-34 | .528 | Yankee Stadium · The Bronx, NY |
| 73 | Thu Jun 18 | at Yankees | W5-1 | 39-34 | .534 | Yankee Stadium · The Bronx, NY |
| 74 | Fri Jun 19 | at Tigers | L3-4 | 39-35 | .527 | Comerica Park · Detroit, MI |
| 75 | Sat Jun 20 | at Tigers | L1-4 | 39-36 | .520 | Comerica Park · Detroit, MI |
| 76 | Sun Jun 21 | at Tigers | L4-5 (10) | 39-37 | .513 | Comerica Park · Detroit, MI |
| 77 | Mon Jun 22 | vs Guardians | W6-5 | 40-37 | .519 | Guaranteed Rate Field · Chicago, IL |
| 78 | Tue Jun 23 | vs Guardians | W2-1 | 41-37 | .526 | Guaranteed Rate Field · Chicago, IL |
| 79 | Wed Jun 24 | vs Guardians | L3-4 (10) | 41-38 | .519 | Guaranteed Rate Field · Chicago, IL |
| 80 | Fri Jun 26 | vs Royals | W22-1 | 42-38 | .525 | Guaranteed Rate Field · Chicago, IL |
| 81 | Sat Jun 27 | vs Royals | W2-1 | 43-38 | .531 | Guaranteed Rate Field · Chicago, IL |
| 82 | Sun Jun 28 | vs Royals | L4-5 | 43-39 | .524 | Guaranteed Rate Field · Chicago, IL |
| 83 | Mon Jun 29 | at Orioles | W8-2 | 44-39 | .530 | Camden Yards · Baltimore, MD |
| 84 | Tue Jun 30 | at Orioles | W9-3 | 45-39 | .536 | Camden Yards · Baltimore, MD |
| 85 | Wed Jul 1 | at Orioles | L1-6 | 45-40 | .529 | Camden Yards · Baltimore, MD |
| 86 | Thu Jul 2 | at Guardians | L5-6 | 45-41 | .523 | Progressive Field · Cleveland, OH |
| 87 | Fri Jul 3 | at Guardians | L3-4 (10) | 45-42 | .517 | Progressive Field · Cleveland, OH |
| 88 | Sat Jul 4 | at Guardians | W3-1 | 46-42 | .523 | Progressive Field · Cleveland, OH |
| 89 | Sun Jul 5 | at Guardians | W7-6 | 47-42 | .528 | Progressive Field · Cleveland, OH |
| 90 | Tue Jul 7 | vs Red Sox | L1-8 | 47-43 | .522 | Guaranteed Rate Field · Chicago, IL |
| 91 | Wed Jul 8 | vs Red Sox | L0-5 | 47-44 | .516 | Guaranteed Rate Field · Chicago, IL |
| 92 | Thu Jul 9 | vs Red Sox | L1-2 | 47-45 | .511 | Guaranteed Rate Field · Chicago, IL |
| 93 | Fri Jul 10 | vs Athletics | W14-1 | 48-45 | .516 | Guaranteed Rate Field · Chicago, IL |
| 94 | Sat Jul 11 | vs Athletics | W1-0 | 49-45 | .521 | Guaranteed Rate Field · Chicago, IL |
| 95 | Sun Jul 12 | vs Athletics | W9-1 | 50-45 | .526 | Guaranteed Rate Field · Chicago, IL |