| 1 | Wed Nov 6 | vs N Arizona | W91-52 | 1-0 | 1.000 | #21 | PACN | McKale Center · Tucson, AZ |
| 2 | Sun Nov 10 | vsIllinois | W90-69 | 2-0 | 1.000 | #21 | PACN | McKale Center · Tucson, AZ |
| 3 | Thu Nov 14 | vsSan Jose St | W87-39 | 3-0 | 1.000 | #19 | PACN | McKale Center · Tucson, AZ |
| 4 | Sun Nov 17 | vsNew Mexico St | W83-53 | 4-0 | 1.000 | #19 | PACN | McKale Center · Tucson, AZ |
| 5 | Thu Nov 21 | vsS Dakota St | W71-64 | 5-0 | 1.000 | #14 | PACN | McKale Center · Tucson, AZ |
| 6 | Sun Nov 24 | vsLong Beach St | W104-67 | 6-0 | 1.000 | - | PACN | McKale Center · Tucson, AZ |
| 7 | Thu Nov 28 | vsPepperdine | W93-91 | 7-0 | 1.000 | - | ESPN2 | McKale Center · Tucson, AZ |
| 8 | Fri Nov 29 | vsPenn | W92-82 | 8-0 | 1.000 | - | ESPN2 | McKale Center · Tucson, AZ |
| 9 | Sun Dec 1 | vsWake Forest | W73-66 | 9-0 | 1.000 | - | ESPN | McKale Center · Tucson, AZ |
| 10 | Sat Dec 7 | at18Baylor | L58-63 | 9-1 | .900 | #12 | ESPNU | Ferrell Center · Waco, TX |
| 11 | Wed Dec 11 | vsOmaha | W99-49 | 10-1 | .909 | #15 | PACN | McKale Center · Tucson, AZ |
| 12 | Sat Dec 14 | vs6Gonzaga | L80-84 | 10-2 | .833 | #15 | ESPN2 | McKale Center · Tucson, AZ |
| 13 | Sat Dec 21 | vsSt John's | L67-70 | 10-3 | .769 | - | ESPN2 | Chase Center · San Francisco, CA |
| 14 | Sat Jan 4 | vsArizona St | W75-47 | 11-3 | .786 | #25 | PACN | McKale Center · Tucson, AZ |
| 15 | Thu Jan 9 | at9Oregon | L73-74 (OT) | 11-4 | .733 | #24 | ESPN | Matthew Knight Arena · Eugene, OR |
| 16 | Sun Jan 12 | atOregon St | L65-82 | 11-5 | .688 | #24 | FS1 | Gill Coliseum · Corvallis, OR |
| 17 | Thu Jan 16 | vsUtah | W93-77 | 12-5 | .706 | - | PACN | McKale Center · Tucson, AZ |
| 18 | Sat Jan 18 | vs20Colorado | W75-54 | 13-5 | .722 | - | FOX | McKale Center · Tucson, AZ |
| 19 | Sat Jan 25 | atArizona St | L65-66 | 13-6 | .684 | #22 | PACN | Desert Financial Arena · Tempe, AZ |
| 20 | Thu Jan 30 | atWashington | W75-72 | 14-6 | .700 | - | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 21 | Sat Feb 1 | atWashington St | W66-49 | 15-6 | .714 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 22 | Thu Feb 6 | vsUSC | W85-80 | 16-6 | .727 | #23 | ESPN2 | McKale Center · Tucson, AZ |
| 23 | Sat Feb 8 | vsUCLA | L52-65 | 16-7 | .696 | #23 | ESPN2 | McKale Center · Tucson, AZ |
| 24 | Thu Feb 13 | atCalifornia | W68-52 | 17-7 | .708 | - | FS1 | Haas Pavilion · Berkeley, CA |
| 25 | Sat Feb 15 | atStanford | W69-60 | 18-7 | .720 | - | PACN | Maples Pavilion · Stanford, CA |
| 26 | Thu Feb 20 | vsOregon St | W89-63 | 19-7 | .731 | #24 | PACN | McKale Center · Tucson, AZ |
| 27 | Sat Feb 22 | vs14Oregon | L72-73 (OT) | 19-8 | .704 | #24 | ESPN | McKale Center · Tucson, AZ |
| 28 | Thu Feb 27 | atUSC | L48-57 | 19-9 | .679 | - | ESPN | Galen Center · Los Angeles, CA |
| 29 | Sat Feb 29 | atUCLA | L64-69 | 19-10 | .655 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 30 | Thu Mar 5 | vsWashington St | W83-62 | 20-10 | .667 | - | FS1 | McKale Center · Tucson, AZ |
| 31 | Sat Mar 7 | vsWashington | L63-69 | 20-11 | .645 | - | ESPN | McKale Center · Tucson, AZ |
| 32 | Wed Mar 11 | vsWashington | W77-70 | 21-11 | .656 | - | PACN | T-Mobile Arena · Las Vegas, NV |
