| 1 | Mon Nov 3 | vs 3Florida | W93-87 | 1-0 | 1.000 | #13 | TNT | T-Mobile Arena · Las Vegas, NV |
| 2 | Fri Nov 7 | vsUtah Tech | W93-67 | 2-0 | 1.000 | #13 | TNT | McKale Center · Tucson, AZ |
| 3 | Tue Nov 11 | vsN Arizona | W84-49 | 3-0 | 1.000 | #5 | ESPN+ | McKale Center · Tucson, AZ |
| 4 | Fri Nov 14 | at15UCLA | W69-65 | 4-0 | 1.000 | #5 | Peacock | Intuit Dome · Inglewood, CA |
| 5 | Wed Nov 19 | at3UConn | W71-67 | 5-0 | 1.000 | #4 | FS1 | Gampel Pavilion · Storrs, CT |
| 6 | Mon Nov 24 | vsDenver | W103-73 | 6-0 | 1.000 | #2 | CBSSN | McKale Center · Tucson, AZ |
| 7 | Sat Nov 29 | vsNorfolk St | W98-61 | 7-0 | 1.000 | #2 | ESPN+ | McKale Center · Tucson, AZ |
| 8 | Sat Dec 6 | vs20Auburn | W97-68 | 8-0 | 1.000 | #2 | ESPN | McKale Center · Tucson, AZ |
| 9 | Sat Dec 13 | at12Alabama | W96-75 | 9-0 | 1.000 | #1 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 10 | Tue Dec 16 | vsAbilene Chrstn | W96-62 | 10-0 | 1.000 | #1 | ESPN+ | McKale Center · Tucson, AZ |
| 11 | Sat Dec 20 | vsSDSU | W68-45 | 11-0 | 1.000 | #1 | ESPN2 | Mortgage Matchup Center · Phoenix, AZ |
| 12 | Mon Dec 22 | vsBethune | W107-71 | 12-0 | 1.000 | #1 | ESPN+ | McKale Center · Tucson, AZ |
| 13 | Mon Dec 29 | vsS Dakota St | W99-71 | 13-0 | 1.000 | #1 | ESPN+ | McKale Center · Tucson, AZ |
| 14 | Sat Jan 3 | atUtah | W97-78 | 14-0 | 1.000 | #1 | Peacock | Jon M. Huntsman Center · Salt Lake City, UT |
| 15 | Wed Jan 7 | vsKansas St | W101-76 | 15-0 | 1.000 | #1 | FS1 | McKale Center · Tucson, AZ |
| 16 | Sat Jan 10 | atTCU | W86-73 | 16-0 | 1.000 | #1 | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 17 | Wed Jan 14 | vsArizona St | W89-82 | 17-0 | 1.000 | #1 | FS1 | McKale Center · Tucson, AZ |
| 18 | Sat Jan 17 | atUCF | W84-77 | 18-0 | 1.000 | #1 | ESPN | Addition Financial Arena · Orlando, FL |
| 19 | Wed Jan 21 | vsCincinnati | W77-51 | 19-0 | 1.000 | #1 | FS1 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 24 | vsWest Virginia | W88-53 | 20-0 | 1.000 | #1 | CBS | McKale Center · Tucson, AZ |
| 21 | Mon Jan 26 | at13BYU | W86-83 | 21-0 | 1.000 | #1 | ESPN | Marriott Center · Provo, UT |
| 22 | Sat Jan 31 | atArizona St | W87-74 | 22-0 | 1.000 | #1 | TNT | Desert Financial Arena · Tempe, AZ |
| 23 | Sat Feb 7 | vsOklahoma St | W84-47 | 23-0 | 1.000 | #1 | ESPN | McKale Center · Tucson, AZ |
| 24 | Mon Feb 9 | at9Kansas | L78-82 | 23-1 | .958 | #1 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 14 | vs16Texas Tech | L75-78 (OT) | 23-2 | .920 | #1 | ESPN | McKale Center · Tucson, AZ |
| 26 | Wed Feb 18 | vs23BYU | W75-68 | 24-2 | .923 | #4 | ESPN | McKale Center · Tucson, AZ |
| 27 | Sat Feb 21 | at2Houston | W73-66 | 25-2 | .926 | #4 | ABC | Fertitta Center · Houston, TX |
| 28 | Tue Feb 24 | atBaylor | W87-80 | 26-2 | .929 | #2 | ESPN2 | Ferrell Center · Waco, TX |
| 29 | Sat Feb 28 | vs14Kansas | W84-61 | 27-2 | .931 | #2 | ESPN | McKale Center · Tucson, AZ |
