| 1 | Mon Nov 6 | vs Morgan St | W122-59 | 1-0 | 1.000 | #12 | PACN | McKale Center · Tucson, AZ |
| 2 | Fri Nov 10 | at2Duke | W78-73 | 2-0 | 1.000 | #12 | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 3 | Mon Nov 13 | vsSouthern | W97-59 | 3-0 | 1.000 | #3 | PACN | McKale Center · Tucson, AZ |
| 4 | Fri Nov 17 | vsBelmont | W100-68 | 4-0 | 1.000 | #3 | PACN | McKale Center · Tucson, AZ |
| 5 | Sun Nov 19 | vsUT Arlington | W101-56 | 5-0 | 1.000 | #3 | PACN | McKale Center · Tucson, AZ |
| 6 | Thu Nov 23 | vs21Michigan St | W74-68 | 6-0 | 1.000 | #3 | FOX | McKale Center · Tucson, AZ |
| 7 | Sat Dec 2 | vsColgate | W82-55 | 7-0 | 1.000 | #2 | PACN | McKale Center · Tucson, AZ |
| 8 | Sat Dec 9 | vs23Wisconsin | W98-73 | 8-0 | 1.000 | #1 | ESPN | McKale Center · Tucson, AZ |
| 9 | Sat Dec 16 | at3Purdue | L84-92 | 8-1 | .889 | #1 | | Mackey Arena · West Lafayette, IN |
| 10 | Wed Dec 20 | vsAlabama | W87-74 | 9-1 | .900 | #4 | ESPN | Mortgage Matchup Center · Phoenix, AZ |
| 11 | Sat Dec 23 | vs14FAU | L95-96 (2OT) | 9-2 | .818 | #4 | FOX | T-Mobile Arena · Las Vegas, NV |
| 12 | Fri Dec 29 | atCalifornia | W100-81 | 10-2 | .833 | #4 | PACN | Haas Pavilion · Berkeley, CA |
| 13 | Sun Dec 31 | atStanford | L82-100 | 10-3 | .769 | #4 | PACN | Maples Pavilion · Stanford, CA |
| 14 | Thu Jan 4 | vsColorado | W97-50 | 11-3 | .786 | #10 | ESPN | McKale Center · Tucson, AZ |
| 15 | Sat Jan 6 | vsUtah | W92-73 | 12-3 | .800 | #10 | PACN | McKale Center · Tucson, AZ |
| 16 | Sat Jan 13 | atWashington St | L70-73 | 12-4 | .750 | #8 | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 17 | Wed Jan 17 | vsUSC | W82-67 | 13-4 | .765 | #12 | ESPN | McKale Center · Tucson, AZ |
| 18 | Sat Jan 20 | vsUCLA | W77-71 | 14-4 | .778 | #12 | ESPN2 | McKale Center · Tucson, AZ |
| 19 | Thu Jan 25 | atOregon St | L80-83 | 14-5 | .737 | #9 | PACN | Gill Coliseum · Corvallis, OR |
| 20 | Sat Jan 27 | atOregon | W87-78 | 15-5 | .750 | #9 | FOX | Matthew Knight Arena · Eugene, OR |
| 21 | Thu Feb 1 | vsCalifornia | W91-65 | 16-5 | .762 | #11 | PACN | McKale Center · Tucson, AZ |
| 22 | Sun Feb 4 | vsStanford | W82-71 | 17-5 | .773 | #11 | FS1 | McKale Center · Tucson, AZ |
| 23 | Thu Feb 8 | atUtah | W105-99 (3OT) | 18-5 | .783 | #8 | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 24 | Sat Feb 10 | atColorado | W99-79 | 19-5 | .792 | #8 | ESPN | CU Events Center · Boulder, CO |
| 25 | Sat Feb 17 | vsArizona St | W105-60 | 20-5 | .800 | #5 | | McKale Center · Tucson, AZ |
| 26 | Thu Feb 22 | vs21Washington St | L74-77 | 20-6 | .769 | #4 | FS1 | McKale Center · Tucson, AZ |
| 27 | Sat Feb 24 | vsWashington | W91-75 | 21-6 | .778 | #4 | CBS | McKale Center · Tucson, AZ |
| 28 | Wed Feb 28 | atArizona St | W85-67 | 22-6 | .786 | #6 | PACN | Desert Financial Arena · Tempe, AZ |
| 29 | Sat Mar 2 | vsOregon | W103-83 | 23-6 | .793 | #6 | ESPN | McKale Center · Tucson, AZ |
| 30 | Thu Mar 7 | atUCLA | W88-65 | 24-6 | .800 | #5 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 31 | Sat Mar 9 | atUSC | L65-78 | 24-7 | .774 | #5 | ESPN | Galen Center · Los Angeles, CA |
| 32 | Thu Mar 14 | vsUSC | W70-49 | 25-7 | .781 | #6 | PACN | T-Mobile Arena · Las Vegas, NV |
| 33 | Fri Mar 15 | vsOregon | L59-67 | 25-8 | .758 | #6 | PACN | T-Mobile Arena · Las Vegas, NV |
| 34 | Thu Mar 21 | vs15Long Beach St | W85-65 | 26-8 | .765 | #2 | TBS | Delta Center · Salt Lake City, UT |
| 35 | Sat Mar 23 | vs7Dayton | W78-68 | 27-8 | .771 | #2 | CBS | Delta Center · Salt Lake City, UT |
| 36 | Thu Mar 28 | vs6Clemson | L72-77 | 27-9 | .750 | #2 | CBS | McKale Center · Tucson, AZ |
