| 1 | Tue Nov 9 | vs N Arizona | W81-52 | 1-0 | 1.000 | - | PACN | McKale Center · Tucson, AZ |
| 2 | Fri Nov 12 | vs UT Rio Grande | W104-50 | 2-0 | 1.000 | - | PACN | McKale Center · Tucson, AZ |
| 3 | Tue Nov 16 | vs N Dakota St | W97-45 | 3-0 | 1.000 | - | PACN | McKale Center · Tucson, AZ |
| 4 | Fri Nov 19 | vs Wichita St | W82-78 (OT) | 4-0 | 1.000 | - | ESPNU | McKale Center · Tucson, AZ |
| 5 | Sun Nov 21 | vs Michigan | W80-62 | 5-0 | 1.000 | - | ESPN | McKale Center · Tucson, AZ |
| 6 | Sat Nov 27 | vs Sacramento St | W105-59 | 6-0 | 1.000 | #17 | PACN | McKale Center · Tucson, AZ |
| 7 | Thu Dec 2 | vs Washington | PPD | 33-4 | .892 | #11 | | McKale Center · Tucson, AZ |
| 8 | Sun Dec 5 | at Oregon St | W90-65 | 7-0 | 1.000 | #11 | ESPNU | Gill Coliseum · Corvallis, OR |
| 9 | Wed Dec 8 | vs Wyoming | W94-65 | 8-0 | 1.000 | #11 | PACN | McKale Center · Tucson, AZ |
| 10 | Sat Dec 11 | at Illinois | W83-79 | 9-0 | 1.000 | #11 | FOX | State Farm Center · Champaign, IL |
| 11 | Wed Dec 15 | vs N Colorado | W101-76 | 10-0 | 1.000 | #8 | PACN | McKale Center · Tucson, AZ |
| 12 | Sat Dec 18 | vs CA Baptist | W84-60 | 11-0 | 1.000 | #8 | PACN | McKale Center · Tucson, AZ |
| 13 | Wed Dec 22 | at #19Tennessee | L73-77 | 11-1 | .917 | #6 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 14 | Thu Dec 30 | at #5UCLA | PPD | 33-4 | .892 | #9 | | Pauley Pavilion · Los Angeles, CA |
| 15 | Sun Jan 2 | at #7USC | PPD | 33-4 | .892 | #9 | | Galen Center · Los Angeles, CA |
| 16 | Mon Jan 3 | vsWashington | W95-79 | 12-1 | .923 | #8 | PACN | McKale Center · Tucson, AZ |
| 17 | Sat Jan 8 | at Arizona St | PPD | 33-4 | .892 | #8 | | Desert Financial Arena · Tempe, AZ |
| 18 | Thu Jan 13 | vs Colorado | W76-55 | 13-1 | .929 | #6 | FS1 | McKale Center · Tucson, AZ |
| 19 | Sat Jan 15 | vs Utah | W82-64 | 14-1 | .933 | #6 | PACN | McKale Center · Tucson, AZ |
| 20 | Thu Jan 20 | at Stanford | W85-57 | 15-1 | .938 | #3 | ESPNU | Maples Pavilion · Stanford, CA |
| 21 | Sun Jan 23 | at California | W96-71 | 16-1 | .941 | #3 | PACN | Haas Pavilion · Berkeley, CA |
| 22 | Tue Jan 25 | at#7UCLA | L59-75 | 16-2 | .889 | #3 | ESPN | Pauley Pavilion · Los Angeles, CA |
| 23 | Sat Jan 29 | vsArizona St | W67-56 | 17-2 | .895 | #3 | CBS | McKale Center · Tucson, AZ |
| 24 | Thu Feb 3 | vs#3UCLA | W76-66 | 18-2 | .900 | #7 | ESPN | McKale Center · Tucson, AZ |
| 25 | Sat Feb 5 | vs#19USC | W72-63 | 19-2 | .905 | #7 | FOX | McKale Center · Tucson, AZ |
| 26 | Mon Feb 7 | atArizona St | W91-79 | 20-2 | .909 | #4 | FS1 | Desert Financial Arena · Tempe, AZ |
| 27 | Thu Feb 10 | at Washington St | W72-60 | 21-2 | .913 | #4 | FS1 | Friel Court at Beasley Coliseum · Pullman, WA |
| 28 | Sat Feb 12 | atWashington | W92-68 | 22-2 | .917 | #4 | PACN | Alaska Airlines Arena · Seattle, WA |
| 29 | Thu Feb 17 | vsOregon St | W83-69 | 23-2 | .920 | #3 | PACN | McKale Center · Tucson, AZ |
| 30 | Sat Feb 19 | vs Oregon | W84-81 | 24-2 | .923 | #3 | ESPN | McKale Center · Tucson, AZ |
| 31 | Thu Feb 24 | atUtah | W97-77 | 25-2 | .926 | #2 | FS1 | Jon M. Huntsman Center · Salt Lake City, UT |
| 32 | Sat Feb 26 | atColorado | L63-79 | 25-3 | .893 | #2 | ESPN2 | CU Events Center · Boulder, CO |
| 33 | Tue Mar 1 | at#16USC | W91-71 | 26-3 | .897 | #2 | ESPN | Galen Center · Los Angeles, CA |
| 34 | Thu Mar 3 | vsStanford | W81-69 | 27-3 | .900 | #2 | ESPN2 | McKale Center · Tucson, AZ |
| 35 | Sat Mar 5 | vsCalifornia | W89-61 | 28-3 | .903 | #2 | | McKale Center · Tucson, AZ |
| 36 | Thu Mar 10 | vsStanford | W84-80 | 29-3 | .906 | - | PACN | McKale Center · Tucson, AZ |
| 37 | Fri Mar 11 | vsColorado | W82-72 | 30-3 | .909 | - | PACN | McKale Center · Tucson, AZ |
| 38 | Sat Mar 12 | vsUCLA | W84-76 | 31-3 | .912 | - | FOX | McKale Center · Tucson, AZ |
| 39 | Fri Mar 18 | vs #16Wright St | W87-70 | 32-3 | .914 | #1 | truTV | McKale Center · Tucson, AZ |
| 40 | Sun Mar 20 | vs #9TCU | W85-80 (OT) | 33-3 | .917 | #1 | TBS | McKale Center · Tucson, AZ |
| 41 | Thu Mar 24 | vs #5Houston | L60-72 | 33-4 | .892 | #1 | TBS | McKale Center · Tucson, AZ |
