| 1 | Mon Nov 3 | vs Missouri | L67-88 | 0-1 | .000 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 2 | Thu Nov 6 | vsTBD | W103-71 | 1-1 | .500 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 3 | Sun Nov 9 | vsGrambling | L70-73 | 1-2 | .333 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 4 | Thu Nov 13 | vsAlcorn St | W72-64 | 2-2 | .500 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 5 | Wed Nov 19 | atStetson | L60-64 | 2-3 | .400 | - | ESPN+ | Edmunds Center · Deland, FL |
| 6 | Sat Nov 22 | vsNiagara | W80-70 | 3-3 | .500 | - | ACC Extra | Cameron Indoor Stadium · Durham, NC |
| 7 | Sun Nov 23 | at5Duke | L56-93 | 3-4 | .429 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 8 | Wed Nov 26 | vsTBD | W115-61 | 4-4 | .500 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 9 | Sat Nov 29 | atMount St Mary | L75-79 | 4-5 | .444 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 10 | Sat Dec 6 | vsTBD | W85-69 | 5-5 | .500 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 11 | Tue Dec 9 | vsNC A&T | W73-69 | 6-5 | .545 | - | | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 13 | vsHampton | W61-57 | 7-5 | .583 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 13 | Tue Dec 16 | atDrexel | W74-66 | 8-5 | .615 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Sat Dec 20 | atUNC Wilmington | W67-66 | 9-5 | .643 | - | | Trask Coliseum · Wilmington, NC |
| 15 | Tue Dec 30 | atNorthwestern | L60-80 | 9-6 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 16 | Sat Jan 3 | atSC State | L57-58 | 9-7 | .563 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 17 | Sat Jan 10 | atMD-Eastern | L57-69 | 9-8 | .529 | - | | Hytche Athletic Center · Princess Anne, MD |
| 18 | Mon Jan 12 | vsDelaware St | W84-58 | 10-8 | .556 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 19 | Sat Jan 17 | atNC Central | W83-69 | 11-8 | .579 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 20 | Mon Jan 19 | vsTBD | W78-69 | 12-8 | .600 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 21 | Sat Jan 24 | vsMorgan St | L77-78 | 12-9 | .571 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 22 | Mon Jan 26 | atCoppin St | PPD | 19-10 | .655 | - | | Physical Education Complex · Baltimore, MD |
| 23 | Sat Jan 31 | vsNorfolk St | W88-60 | 13-9 | .591 | - | ESPNU | Burr Gymnasium · Washington, D.C. |
| 24 | Mon Feb 2 | atCoppin St | W72-53 | 14-9 | .609 | - | | Physical Education Complex · Baltimore, MD |
| 25 | Sat Feb 7 | vsSC State | W85-57 | 15-9 | .625 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 26 | Mon Feb 9 | vsYale | L81-87 (OT) | 15-10 | .600 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 27 | Sat Feb 14 | vsMD-Eastern | W79-53 | 16-10 | .615 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 28 | Mon Feb 16 | atDelaware St | W91-59 | 17-10 | .630 | - | ESPN+ | Memorial Hall (Dover, DE) · Dover, DE |
| 29 | Sat Feb 21 | vsNC Central | W100-67 | 18-10 | .643 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 30 | Sat Feb 28 | atMorgan St | W84-59 | 19-10 | .655 | - | ESPN+ | Hill Field House · Baltimore, MD |
