| 1 | Wed Nov 6 | vs Belmont | W79-72 | 1-0 | 1.000 | - | | Redbird Arena · Normal, IL |
| 2 | Sun Nov 10 | vs Little Rock | W75-70 | 2-0 | 1.000 | - | | Redbird Arena · Normal, IL |
| 3 | Sun Nov 17 | vs UCF | L65-67 | 2-1 | .667 | - | | Redbird Arena · Normal, IL |
| 4 | Fri Nov 22 | at Cincinnati | L65-66 | 2-2 | .500 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Sat Nov 23 | at Western KY | L69-83 | 2-3 | .400 | - | | E. A. Diddle Arena · Bowling Green, KY |
| 6 | Mon Nov 25 | vs Grand Canyon | L63-68 | 2-4 | .333 | - | | Redbird Arena · Normal, IL |
| 7 | Fri Nov 29 | vs TBD | W76-57 | 3-4 | .429 | - | | Redbird Arena · Normal, IL |
| 8 | Tue Dec 3 | at TCU | L69-81 | 3-5 | .375 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 9 | Sat Dec 7 | vs Morehead St | W61-50 | 4-5 | .444 | - | | Redbird Arena · Normal, IL |
| 10 | Sun Dec 15 | at N Kentucky | L64-79 | 4-6 | .400 | - | | Truist Arena · Highland Heights, KY |
| 11 | Wed Dec 18 | vs UIC | W67-66 | 5-6 | .455 | - | | Redbird Arena · Normal, IL |
| 12 | Sat Dec 21 | at UTSA | L70-89 | 5-7 | .417 | - | | UTSA Convocation Center · San Antonio, TX |
| 13 | Tue Dec 31 | vs Northern Iowa | W76-70 | 6-7 | .462 | - | | Redbird Arena · Normal, IL |
| 14 | Sat Jan 4 | at S Illinois | L55-67 | 6-8 | .429 | - | | Banterra Center · Carbondale, IL |
| 15 | Tue Jan 7 | vs Missouri St | L63-67 | 6-9 | .400 | - | | Redbird Arena · Normal, IL |
| 16 | Sat Jan 11 | at Indiana St | L52-65 | 6-10 | .375 | - | | Hulman Center · Terre Haute, IN |
| 17 | Thu Jan 16 | at Drake | L74-84 | 6-11 | .353 | - | | The Knapp Center · Des Moines, IA |
| 18 | Sun Jan 19 | vs Loyola Chicago | L50-62 | 6-12 | .333 | - | ESPNU | Redbird Arena · Normal, IL |
| 19 | Wed Jan 22 | at Bradley | L63-75 | 6-13 | .316 | - | | Carver Arena · Peoria, IL |
| 20 | Sat Jan 25 | vsS Illinois | L55-58 | 6-14 | .300 | - | | Redbird Arena · Normal, IL |
| 21 | Wed Jan 29 | vs Evansville | W77-66 | 7-14 | .333 | - | | Redbird Arena · Normal, IL |
| 22 | Sat Feb 1 | at Valparaiso | L70-80 | 7-15 | .318 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 23 | Wed Feb 5 | atMissouri St | L60-80 | 7-16 | .304 | - | | Great Southern Bank Arena · Springfield, MO |
| 24 | Sat Feb 8 | vsIndiana St | W74-67 | 8-16 | .333 | - | | Redbird Arena · Normal, IL |
| 25 | Wed Feb 12 | atNorthern Iowa | L63-71 | 8-17 | .320 | - | | McLeod Center · Cedar Falls, IA |
| 26 | Sat Feb 15 | vsValparaiso | L62-65 | 8-18 | .308 | - | | Redbird Arena · Normal, IL |
| 27 | Wed Feb 19 | atLoyola Chicago | L69-84 | 8-19 | .296 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Sat Feb 22 | vsDrake | W57-53 | 9-19 | .321 | - | | Redbird Arena · Normal, IL |
| 29 | Wed Feb 26 | vsBradley | L71-74 (OT) | 9-20 | .310 | - | CBS | Redbird Arena · Normal, IL |
| 30 | Sat Feb 29 | atEvansville | W71-60 | 10-20 | .333 | - | | Ford Center · Evansville, IN |
| 31 | Thu Mar 5 | atDrake | L65-75 | 10-21 | .323 | - | | The Knapp Center · Des Moines, IA |
