| 1 | Mon Nov 7 | vs UL Monroe | W87-54 | 1-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 2 | Fri Nov 11 | vs Abilene Chrstn | W77-58 | 2-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 3 | Thu Nov 17 | vs Murray St | L79-88 | 2-1 | .667 | - | ESPN2 | Reed Arena · College Station, TX |
| 4 | Fri Nov 18 | vs Colorado | L75-103 | 2-2 | .500 | - | ESPNU | Reed Arena · College Station, TX |
| 5 | Sun Nov 20 | at Loyola Chicago | W67-51 | 3-2 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Fri Nov 25 | at DePaul | W82-66 | 4-2 | .667 | - | FS1 | Wintrust Arena · Chicago, IL |
| 7 | Wed Nov 30 | vs SMU | W83-64 | 5-2 | .714 | - | | Reed Arena · College Station, TX |
| 8 | Sat Dec 3 | vs Boise St | L71-86 | 5-3 | .625 | - | ESPNU | Reed Arena · College Station, TX |
| 9 | Sun Dec 11 | vs Oregon St | W72-54 | 6-3 | .667 | - | ESPN2 | Reed Arena · College Station, TX |
| 10 | Sat Dec 17 | at Memphis | L79-83 | 6-4 | .600 | - | ESPNU | FedExForum · Memphis, TN |
| 11 | Tue Dec 20 | vs Wofford | L62-67 | 6-5 | .545 | - | | Reed Arena · College Station, TX |
| 12 | Tue Dec 27 | vs N'Western St | W64-52 | 7-5 | .583 | - | SEC Network | Reed Arena · College Station, TX |
| 13 | Fri Dec 30 | vs Prairie View | W86-66 | 8-5 | .615 | - | | Reed Arena · College Station, TX |
| 14 | Wed Jan 4 | at Florida | W66-63 | 9-5 | .643 | - | ESPNU | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 15 | Sat Jan 7 | vs LSU | W69-56 | 10-5 | .667 | - | SEC Network | Reed Arena · College Station, TX |
| 16 | Wed Jan 11 | vs #20Missouri | W82-64 | 11-5 | .688 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Sat Jan 14 | at South Carolina | W94-53 | 12-5 | .706 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 18 | Wed Jan 18 | vsFlorida | W54-52 | 13-5 | .722 | - | SEC Network | Reed Arena · College Station, TX |
| 19 | Sat Jan 21 | at Kentucky | L67-76 | 13-6 | .684 | - | ESPN | Rupp Arena · Lexington, KY |
| 20 | Wed Jan 25 | at #15Auburn | W79-63 | 14-6 | .700 | - | ESPN2 | Neville Arena · Auburn, AL |
| 21 | Sat Jan 28 | vs Vanderbilt | W72-66 | 15-6 | .714 | - | SEC Network | Reed Arena · College Station, TX |
| 22 | Tue Jan 31 | at Arkansas | L70-81 | 15-7 | .682 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 23 | Sat Feb 4 | vs Georgia | W82-57 | 16-7 | .696 | - | SEC Network | Reed Arena · College Station, TX |
| 24 | Tue Feb 7 | vsAuburn | W83-78 | 17-7 | .708 | - | ESPN2 | Reed Arena · College Station, TX |
| 25 | Sat Feb 11 | atLSU | W74-62 | 18-7 | .720 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 26 | Wed Feb 15 | vsArkansas | W62-56 | 19-7 | .731 | - | ESPN2 | Reed Arena · College Station, TX |
| 27 | Sat Feb 18 | atMissouri | W69-60 | 20-7 | .741 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 28 | Tue Feb 21 | vs #11Tennessee | W68-63 | 21-7 | .750 | #25 | ESPN | Reed Arena · College Station, TX |
| 29 | Sat Feb 25 | at Mississippi St | L62-69 | 21-8 | .724 | #25 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 30 | Tue Feb 28 | at Ole Miss | W69-61 | 22-8 | .733 | #24 | ESPNU | SJB Pavilion · Oxford, MS |
| 31 | Sat Mar 4 | vs #2Alabama | W67-61 | 23-8 | .742 | #24 | CBS | Reed Arena · College Station, TX |
| 32 | Fri Mar 10 | vsArkansas | W67-61 | 24-8 | .750 | - | SEC Network | Reed Arena · College Station, TX |
| 33 | Sat Mar 11 | vsVanderbilt | W87-75 | 25-8 | .758 | - | ESPN | Reed Arena · College Station, TX |
| 34 | Sun Mar 12 | atAlabama | L63-82 | 25-9 | .735 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 35 | Thu Mar 16 | vs #10Penn State | L59-76 | 25-10 | .714 | #7 | TBS | Reed Arena · College Station, TX |
