| 1 | Sun Sep 8 | vs Steelers | L10-18 | 0-1 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Mon Sep 16 | atEagles | W22-21 | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 3 | Sun Sep 22 | vsChiefs | L17-22 | 1-2 | .333 | Mercedes-Benz Stadium · Atlanta, GA |
| 4 | Sun Sep 29 | vsSaints | W26-24 | 2-2 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 5 | Thu Oct 3 | vsBuccaneers | W36-30 (OT) | 3-2 | .600 | Mercedes-Benz Stadium · Atlanta, GA |
| 6 | Sun Oct 13 | atPanthers | W38-20 | 4-2 | .667 | Bank of America Stadium · Charlotte, NC |
| 7 | Sun Oct 20 | vsSeahawks | L14-34 | 4-3 | .571 | Mercedes-Benz Stadium · Atlanta, GA |
| 8 | Sun Oct 27 | atBuccaneers | W31-26 | 5-3 | .625 | Raymond James Stadium · Tampa, FL |
| 9 | Sun Nov 3 | vsCowboys | W27-21 | 6-3 | .667 | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sun Nov 10 | atSaints | L17-20 | 6-4 | .600 | Caesars Superdome · New Orleans, LA |
| 11 | Sun Nov 17 | atBroncos | L6-38 | 6-5 | .545 | Empower Field at Mile High · Denver, CO |
| --bye week-- |
| 13 | Sun Dec 1 | vsChargers | L13-17 | 6-6 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 14 | Sun Dec 8 | atVikings | L21-42 | 6-7 | .462 | U.S. Bank Stadium · Minneapolis, MN |
| 15 | Mon Dec 16 | atRaiders | W15-9 | 7-7 | .500 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sun Dec 22 | vsGiants | W34-7 | 8-7 | .533 | Mercedes-Benz Stadium · Atlanta, GA |
| 17 | Sun Dec 29 | atCommanders | L24-30 (OT) | 8-8 | .500 | FedEx Field · North Englewood, MD |
| 18 | Sun Jan 5 | vsPanthers | L38-44 (OT) | 8-9 | .471 | Mercedes-Benz Stadium · Atlanta, GA |
