| 1 | Sun Sep 8 | at Browns | W33-17 | 1-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Sun Sep 15 | vs Saints | L19-44 | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 3 | Sun Sep 22 | vs Ravens | L25-28 | 1-2 | .333 | AT&T Stadium · Arlington, TX |
| 4 | Thu Sep 26 | at Giants | W20-15 | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 6 | at Steelers | W20-17 | 3-2 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 6 | Sun Oct 13 | vs Lions | L9-47 | 3-3 | .500 | AT&T Stadium · Arlington, TX |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 27 | at 49ers | L24-30 | 3-4 | .429 | Levi's® Stadium · Santa Clara, CA |
| 9 | Sun Nov 3 | at Falcons | L21-27 | 3-5 | .375 | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sun Nov 10 | vs Eagles | L6-34 | 3-6 | .333 | AT&T Stadium · Arlington, TX |
| 11 | Mon Nov 18 | vs Texans | L10-34 | 3-7 | .300 | AT&T Stadium · Arlington, TX |
| 12 | Sun Nov 24 | at Commanders | W34-26 | 4-7 | .364 | FedEx Field · North Englewood, MD |
| 13 | Thu Nov 28 | vsGiants | W27-20 | 5-7 | .417 | AT&T Stadium · Arlington, TX |
| 14 | Mon Dec 9 | vs Bengals | L20-27 | 5-8 | .385 | AT&T Stadium · Arlington, TX |
| 15 | Sun Dec 15 | at Panthers | W30-14 | 6-8 | .429 | Bank of America Stadium · Charlotte, NC |
| 16 | Sun Dec 22 | vs Buccaneers | W26-24 | 7-8 | .467 | AT&T Stadium · Arlington, TX |
| 17 | Sun Dec 29 | atEagles | L7-41 | 7-9 | .438 | Lincoln Financial Field · Philadelphia, PA |
| 18 | Sun Jan 5 | vsCommanders | L19-23 | 7-10 | .412 | AT&T Stadium · Arlington, TX |
