| 3 | Sun Sep 22 | at Vikings | 1:00 PM | 2-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Sun Sep 29 | vs Jaguars | 1:00 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 6 | vs Bills | 1:00 PM | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 6 | Sun Oct 13 | at Patriots | 1:00 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| 7 | Sun Oct 20 | at Packers | 1:00 PM | 1-1 | .500 | Lambeau Field · Green Bay, WI |
| 8 | Sun Oct 27 | vs Colts | 1:00 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
| 9 | Thu Oct 31 | at Jets | 8:15 PM | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 10 | vs Lions | 8:20 PM | 1-1 | .500 | NRG Stadium · Houston, TX |
| 11 | Mon Nov 18 | at Cowboys | 8:15 PM | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 12 | Sun Nov 24 | vs Titans | 1:00 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 1 | atJaguars | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 15 | vs Dolphins | 1:00 PM | 1-1 | .500 | NRG Stadium · Houston, TX |
| 16 | Sat Dec 21 | at Chiefs | 1:00 PM | 2-0 | 1.000 | Arrowhead Stadium · Kansas City, MO |
| 17 | Wed Dec 25 | vs Ravens | 4:30 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
Bears