| 3 | Sun Sep 21 | vs Packers | 1:00 PM | 2-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Sep 28 | atLions | 1:00 PM | 1-1 | .500 | Ford Field · Detroit, MI |
| 5 | Sun Oct 5 | vsVikings | 9:30 AM | 1-1 | .500 | Tottenham Hotspur Stadium · London, England |
| 6 | Sun Oct 12 | atSteelers | 1:00 PM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sun Oct 19 | vsDolphins | 1:00 PM | 0-2 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 8 | Sun Oct 26 | atPatriots | 1:00 PM | 1-1 | .500 | Gillette Stadium · Foxborough, MA |
| --bye week-- |
| 10 | Sun Nov 9 | atJets | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 11 | Sun Nov 16 | vsRavens | 4:25 PM | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 23 | atRaiders | 4:05 PM | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 13 | Sun Nov 30 | vs49ers | 1:00 PM | 2-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 14 | Sun Dec 7 | vsTitans | 1:00 PM | 0-2 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 14 | atBears | 1:00 PM | 0-2 | .000 | Soldier Field · Chicago, IL |
| 16 | Sun Dec 21 | vsBills | 1:00 PM | 2-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 17 | Sun Dec 28 | vsSteelers | 1:00 PM | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 18 | TBD | atBengals | TBD | 2-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
