| 1 | Sun Sep 12 | at Chiefs | L29-33 | 0-1 | .000 | Arrowhead Stadium · Kansas City, MO |
| 2 | Sun Sep 19 | vs Texans | W31-21 | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 3 | Sun Sep 26 | vs Bears | W26-6 | 2-1 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 3 | at Vikings | W14-7 | 3-1 | .750 | U.S. Bank Stadium · Minneapolis, MN |
| 5 | Sun Oct 10 | at Chargers | L42-47 | 3-2 | .600 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 17 | vs Cardinals | L14-37 | 3-3 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Thu Oct 21 | vs Broncos | W17-14 | 4-3 | .571 | FirstEnergy Stadium · Cleveland, OH |
| 8 | Sun Oct 31 | vs Steelers | L10-15 | 4-4 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 9 | Sun Nov 7 | at Bengals | W41-16 | 5-4 | .556 | Paycor Stadium · Cincinnati, OH |
| 10 | Sun Nov 14 | at Patriots | L7-45 | 5-5 | .500 | Gillette Stadium · Foxborough, MA |
| 11 | Sun Nov 21 | vs Lions | W13-10 | 6-5 | .545 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 28 | at Ravens | L10-16 | 6-6 | .500 | M&T Bank Stadium · Baltimore, MD |
| 13 | -- BYE WEEK -- |
| 14 | Sun Dec 12 | vsRavens | W24-22 | 7-6 | .538 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Mon Dec 20 | vs Raiders | L14-16 | 7-7 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sat Dec 25 | at Packers | L22-24 | 7-8 | .467 | Lambeau Field · Green Bay, WI |
| 17 | Mon Jan 3 | atSteelers | L14-26 | 7-9 | .438 | Acrisure Stadium · Pittsburgh, PA |
| 18 | Sun Jan 9 | vsBengals | W21-16 | 8-9 | .471 | FirstEnergy Stadium · Cleveland, OH |
