| 6 | Mon Oct 13 | at Commanders | 8:15 PM | 3-2 | .600 | FedEx Field · North Englewood, MD |
| 7 | Sun Oct 19 | vsSaints | 1:00 PM | 1-4 | .200 | Soldier Field · Chicago, IL |
| 8 | Sun Oct 26 | atRavens | 1:00 PM | 1-4 | .200 | M&T Bank Stadium · Baltimore, MD |
| 9 | Sun Nov 2 | atBengals | 1:00 PM | 2-3 | .400 | Paycor Stadium · Cincinnati, OH |
| 10 | Sun Nov 9 | vsGiants | 1:00 PM | 1-4 | .200 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 16 | atVikings | 1:00 PM | 3-2 | .600 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Sun Nov 23 | vsSteelers | 1:00 PM | 3-1 | .750 | Soldier Field · Chicago, IL |
| 13 | Fri Nov 28 | atEagles | 3:00 PM | 4-1 | .800 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Sun Dec 7 | atPackers | 1:00 PM | 2-1-1 | .625 | Lambeau Field · Green Bay, WI |
| 15 | Sun Dec 14 | vsBrowns | 1:00 PM | 1-4 | .200 | Soldier Field · Chicago, IL |
| 16 | TBD | vsPackers | TBD | 2-1-1 | .625 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 28 | at49ers | 8:20 PM | 4-1 | .800 | Levi's® Stadium · Santa Clara, CA |
| 18 | TBD | vsLions | TBD | 4-1 | .800 | Soldier Field · Chicago, IL |
