| 1 | Sun Sep 13 | at Panthers | 1:00 PM | 0-0 | .000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 20 | vsVikings | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 3 | Mon Sep 28 | vsEagles | 8:15 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 4 | Sun Oct 4 | vsJets | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 11 | atPackers | 4:25 PM | 0-0 | .000 | Lambeau Field · Green Bay, WI |
| 6 | Sun Oct 18 | atFalcons | 1:00 PM | 0-0 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| 7 | Thu Oct 22 | vsPatriots | 8:15 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 8 | Mon Nov 2 | atSeahawks | 8:15 PM | 0-0 | .000 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 8 | vsBuccaneers | 8:20 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| --bye week-- |
| 11 | Sun Nov 22 | vsSaints | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 12 | Thu Nov 26 | atLions | 1:00 PM | 0-0 | .000 | Ford Field · Detroit, MI |
| 13 | Sun Dec 6 | vsJaguars | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 14 | Sun Dec 13 | atDolphins | 1:00 PM | 0-0 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 15 | Sat Dec 19 | atBills | 8:20 PM | 0-0 | .000 | Highmark Stadium · Orchard Park, NY |
| 16 | Fri Dec 25 | vsPackers | 1:00 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 17 | Sun Jan 3 | vsLions | 4:25 PM | 0-0 | .000 | Soldier Field · Chicago, IL |
| 18 | TBD | atVikings | TBD | 0-0 | .000 | U.S. Bank Stadium · Minneapolis, MN |
