| 1 | Thu Sep 5 | vs Packers | L3-10 | 0-1 | .000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 15 | at Broncos | W16-14 | 1-1 | .500 | Empower Field at Mile High · Denver, CO |
| 3 | Mon Sep 23 | at Commanders | W31-15 | 2-1 | .667 | FedEx Field · North Englewood, MD |
| 4 | Sun Sep 29 | vs Vikings | W16-6 | 3-1 | .750 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 6 | at Raiders | L21-24 | 3-2 | .600 | Tottenham Hotspur Stadium · London, England |
| 6 | -- BYE WEEK -- |
| 7 | Sun Oct 20 | vs Saints | L25-36 | 3-3 | .500 | Soldier Field · Chicago, IL |
| 8 | Sun Oct 27 | vs Chargers | L16-17 | 3-4 | .429 | Soldier Field · Chicago, IL |
| 9 | Sun Nov 3 | at Eagles | L14-22 | 3-5 | .375 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 10 | vs Lions | W20-13 | 4-5 | .444 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 17 | at Rams | L7-17 | 4-6 | .400 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 24 | vs Giants | W19-14 | 5-6 | .455 | Soldier Field · Chicago, IL |
| 13 | Thu Nov 28 | atLions | W24-20 | 6-6 | .500 | Ford Field · Detroit, MI |
| 14 | Thu Dec 5 | vs Cowboys | W31-24 | 7-6 | .538 | Soldier Field · Chicago, IL |
| 15 | Sun Dec 15 | atPackers | L13-21 | 7-7 | .500 | Lambeau Field · Green Bay, WI |
| 16 | Sun Dec 22 | vs Chiefs | L3-26 | 7-8 | .467 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 29 | atVikings | W21-19 | 8-8 | .500 | U.S. Bank Stadium · Minneapolis, MN |
