| 1 | Sun Sep 11 | vs 49ers | W19-10 | 1-0 | 1.000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 18 | atPackers | L10-27 | 1-1 | .500 | Lambeau Field · Green Bay, WI |
| 3 | Sun Sep 25 | vsTexans | W23-20 | 2-1 | .667 | Soldier Field · Chicago, IL |
| 4 | Sun Oct 2 | atGiants | L12-20 | 2-2 | .500 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 9 | atVikings | L22-29 | 2-3 | .400 | U.S. Bank Stadium · Minneapolis, MN |
| 6 | Thu Oct 13 | vsCommanders | L7-12 | 2-4 | .333 | Soldier Field · Chicago, IL |
| 7 | Mon Oct 24 | atPatriots | W33-14 | 3-4 | .429 | Gillette Stadium · Foxborough, MA |
| 8 | Sun Oct 30 | atCowboys | L29-49 | 3-5 | .375 | AT&T Stadium · Arlington, TX |
| 9 | Sun Nov 6 | vsDolphins | L32-35 | 3-6 | .333 | Soldier Field · Chicago, IL |
| 10 | Sun Nov 13 | vsLions | L30-31 | 3-7 | .300 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 20 | atFalcons | L24-27 | 3-8 | .273 | Mercedes-Benz Stadium · Atlanta, GA |
| 12 | Sun Nov 27 | atJets | L10-31 | 3-9 | .250 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 4 | vsPackers | L19-28 | 3-10 | .231 | Soldier Field · Chicago, IL |
| --bye week-- |
| 15 | Sun Dec 18 | vsEagles | L20-25 | 3-11 | .214 | Soldier Field · Chicago, IL |
| 16 | Sat Dec 24 | vsBills | L13-35 | 3-12 | .200 | Soldier Field · Chicago, IL |
| 17 | Sun Jan 1 | atLions | L10-41 | 3-13 | .188 | Ford Field · Detroit, MI |
| 18 | Sun Jan 8 | vsVikings | L13-29 | 3-14 | .176 | Soldier Field · Chicago, IL |
