| 1 | Sun Sep 10 | vs Packers | L20-38 | 0-1 | .000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 17 | at Buccaneers | L17-27 | 0-2 | .000 | Raymond James Stadium · Tampa, FL |
| 3 | Sun Sep 24 | at Chiefs | L10-41 | 0-3 | .000 | Arrowhead Stadium · Kansas City, MO |
| 4 | Sun Oct 1 | vs Broncos | L28-31 | 0-4 | .000 | Soldier Field · Chicago, IL |
| 5 | Thu Oct 5 | at Commanders | W40-20 | 1-4 | .200 | FedEx Field · North Englewood, MD |
| 6 | Sun Oct 15 | vs Vikings | L13-19 | 1-5 | .167 | Soldier Field · Chicago, IL |
| 7 | Sun Oct 22 | vs Raiders | W30-12 | 2-5 | .286 | Soldier Field · Chicago, IL |
| 8 | Sun Oct 29 | at Chargers | L13-30 | 2-6 | .250 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 5 | at Saints | L17-24 | 2-7 | .222 | Caesars Superdome · New Orleans, LA |
| 10 | Thu Nov 9 | vs Panthers | W16-13 | 3-7 | .300 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 19 | at Lions | L26-31 | 3-8 | .273 | Ford Field · Detroit, MI |
| 12 | Mon Nov 27 | atVikings | W12-10 | 4-8 | .333 | U.S. Bank Stadium · Minneapolis, MN |
| 13 | -- BYE WEEK -- |
| 14 | Sun Dec 10 | vsLions | W28-13 | 5-8 | .385 | Soldier Field · Chicago, IL |
| 15 | Sun Dec 17 | at Browns | L17-20 | 5-9 | .357 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sun Dec 24 | vs Cardinals | W27-16 | 6-9 | .400 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 31 | vs Falcons | W37-17 | 7-9 | .438 | Soldier Field · Chicago, IL |
| 18 | Sun Jan 7 | atPackers | L9-17 | 7-10 | .412 | Lambeau Field · Green Bay, WI |
