| 1 | Sun Sep 8 | vs Titans | W24-17 | 1-0 | 1.000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 15 | atTexans | L13-19 | 1-1 | .500 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 22 | atColts | L16-21 | 1-2 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 4 | Sun Sep 29 | vsRams | W24-18 | 2-2 | .500 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 6 | vsPanthers | W36-10 | 3-2 | .600 | Soldier Field · Chicago, IL |
| 6 | Sun Oct 13 | vsJaguars | W35-16 | 4-2 | .667 | Tottenham Hotspur Stadium · London, England |
| --bye week-- |
| 8 | Sun Oct 27 | atCommanders | L15-18 | 4-3 | .571 | FedEx Field · North Englewood, MD |
| 9 | Sun Nov 3 | atCardinals | L9-29 | 4-4 | .500 | State Farm Stadium · Glendale, AZ |
| 10 | Sun Nov 10 | vsPatriots | L3-19 | 4-5 | .444 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 17 | vsPackers | L19-20 | 4-6 | .400 | Soldier Field · Chicago, IL |
| 12 | Sun Nov 24 | vsVikings | L27-30 (OT) | 4-7 | .364 | Soldier Field · Chicago, IL |
| 13 | Thu Nov 28 | atLions | L20-23 | 4-8 | .333 | Ford Field · Detroit, MI |
| 14 | Sun Dec 8 | at49ers | L13-38 | 4-9 | .308 | Levi's® Stadium · Santa Clara, CA |
| 15 | Mon Dec 16 | atVikings | L12-30 | 4-10 | .286 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Sun Dec 22 | vsLions | L17-34 | 4-11 | .267 | Soldier Field · Chicago, IL |
| 17 | Thu Dec 26 | vsSeahawks | L3-6 | 4-12 | .250 | Soldier Field · Chicago, IL |
