| 3 | Sun Sep 21 | vs Texans | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Sep 28 | at49ers | 4:05 PM | 2-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 5 | Mon Oct 6 | vsChiefs | 8:15 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 12 | vsSeahawks | 1:00 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 7 | Sun Oct 19 | vsRams | 9:30 AM | 2-0 | 1.000 | Wembley Stadium · London, England |
| --bye week-- |
| 9 | Sun Nov 2 | atRaiders | 4:05 PM | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 10 | Sun Nov 9 | atTexans | 1:00 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
| 11 | Sun Nov 16 | vsChargers | 1:00 PM | 2-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 12 | Sun Nov 23 | atCardinals | 4:05 PM | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Nov 30 | atTitans | 1:00 PM | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 14 | Sun Dec 7 | vsColts | 1:00 PM | 2-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 14 | vsJets | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 21 | atBroncos | 4:05 PM | 1-1 | .500 | Empower Field at Mile High · Denver, CO |
| 17 | Sun Dec 28 | atColts | 1:00 PM | 2-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 18 | TBD | vsTitans | TBD | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
