| 3 | Mon Sep 23 | at Bills | 7:30 PM | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Sep 29 | at Texans | 1:00 PM | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 6 | vs Colts | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 13 | at Bears | 9:30 AM | 1-1 | .500 | Tottenham Hotspur Stadium · London, England |
| 7 | Sun Oct 20 | vs Patriots | 9:30 AM | 1-1 | .500 | Wembley Stadium · London, England |
| 8 | Sun Oct 27 | vs Packers | 1:00 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 9 | Sun Nov 3 | at Eagles | 8:20 PM | 1-1 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 10 | vs Vikings | 1:00 PM | 2-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 11 | Sun Nov 17 | at Lions | 1:00 PM | 1-1 | .500 | Ford Field · Detroit, MI |
| 13 | Sun Dec 1 | vsTexans | 1:00 PM | 2-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 8 | at Titans | 1:00 PM | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 15 | vs Jets | 1:00 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 22 | at Raiders | 4:25 PM | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 17 | Sun Dec 29 | vsTitans | 1:00 PM | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 18 | TBD | atColts | TBD | 0-2 | .000 | Lucas Oil Stadium · Indianapolis, IN |
Browns
Dolphins