| 1 | Sun Sep 13 | vs Colts | W27-20 | 1-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 20 | atTitans | L30-33 | 1-1 | .500 | Nissan Stadium · Nashville, TN |
| 3 | Thu Sep 24 | vsDolphins | L13-31 | 1-2 | .333 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Oct 4 | atBengals | L25-33 | 1-3 | .250 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 11 | atTexans | L14-30 | 1-4 | .200 | NRG Stadium · Houston, TX |
| 6 | Sun Oct 18 | vsLions | L16-34 | 1-5 | .167 | TIAA Bank Field · Jacksonville, FL |
| 7 | Sun Oct 25 | atChargers | L29-39 | 1-6 | .143 | SoFi Stadium · Inglewood, CA |
| --bye week-- |
| 9 | Sun Nov 8 | vsTexans | L25-27 | 1-7 | .125 | TIAA Bank Field · Jacksonville, FL |
| 10 | Sun Nov 15 | atPackers | L20-24 | 1-8 | .111 | Lambeau Field · Green Bay, WI |
| 11 | Sun Nov 22 | vsSteelers | L3-27 | 1-9 | .100 | TIAA Bank Field · Jacksonville, FL |
| 12 | Sun Nov 29 | vsBrowns | L25-27 | 1-10 | .091 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 6 | atVikings | L24-27 (OT) | 1-11 | .083 | U.S. Bank Stadium · Minneapolis, MN |
| 14 | Sun Dec 13 | vsTitans | L10-31 | 1-12 | .077 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 20 | atRavens | L14-40 | 1-13 | .071 | M&T Bank Stadium · Baltimore, MD |
| 16 | Sun Dec 27 | vsBears | L17-41 | 1-14 | .067 | TIAA Bank Field · Jacksonville, FL |
| 17 | Sun Jan 3 | atColts | L14-28 | 1-15 | .063 | Lucas Oil Stadium · Indianapolis, IN |
