| 3 | Sun Sep 21 | at Vikings | 1:00 PM | 1-1 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Mon Sep 29 | atBroncos | 8:15 PM | 1-1 | .500 | Empower Field at Mile High · Denver, CO |
| 5 | Sun Oct 5 | vsLions | 4:25 PM | 1-1 | .500 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 12 | atPackers | 4:25 PM | 2-0 | 1.000 | Lambeau Field · Green Bay, WI |
| 7 | Thu Oct 16 | vsSteelers | 8:15 PM | 1-1 | .500 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 26 | vsJets | 1:00 PM | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
| 9 | Sun Nov 2 | vsBears | 1:00 PM | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 11 | Sun Nov 16 | atSteelers | 1:00 PM | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 23 | vsPatriots | 1:00 PM | 1-1 | .500 | Paycor Stadium · Cincinnati, OH |
| 13 | Thu Nov 27 | atRavens | 8:20 PM | 1-1 | .500 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 7 | atBills | 4:25 PM | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 15 | Sun Dec 14 | vsRavens | 1:00 PM | 1-1 | .500 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 21 | atDolphins | 8:20 PM | 0-2 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 17 | TBD | vsCardinals | TBD | 2-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 18 | TBD | vsBrowns | TBD | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
