| 1 | Sun Sep 7 | at Browns | W17-16 | 1-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Sun Sep 14 | vsJaguars | W31-27 | 2-0 | 1.000 | Paycor Stadium · Cincinnati, OH |
| 3 | Sun Sep 21 | atVikings | L10-48 | 2-1 | .667 | U.S. Bank Stadium · Minneapolis, MN |
| 4 | Mon Sep 29 | atBroncos | L3-28 | 2-2 | .500 | Empower Field at Mile High · Denver, CO |
| 5 | Sun Oct 5 | vsLions | L24-37 | 2-3 | .400 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 12 | atPackers | L18-27 | 2-4 | .333 | Lambeau Field · Green Bay, WI |
| 7 | Thu Oct 16 | vsSteelers | W33-31 | 3-4 | .429 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 26 | vsJets | L38-39 | 3-5 | .375 | Paycor Stadium · Cincinnati, OH |
| 9 | Sun Nov 2 | vsBears | L42-47 | 3-6 | .333 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 11 | Sun Nov 16 | atSteelers | L12-34 | 3-7 | .300 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 23 | vsPatriots | L20-26 | 3-8 | .273 | Paycor Stadium · Cincinnati, OH |
| 13 | Thu Nov 27 | atRavens | W32-14 | 4-8 | .333 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 7 | atBills | L34-39 | 4-9 | .308 | Highmark Stadium · Orchard Park, NY |
| 15 | Sun Dec 14 | vsRavens | L0-24 | 4-10 | .286 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 21 | atDolphins | W45-21 | 5-10 | .333 | Hard Rock Stadium · Miami Gardens, FL |
| 17 | Sun Dec 28 | vsCardinals | W37-14 | 6-10 | .375 | Paycor Stadium · Cincinnati, OH |
| 18 | Sun Jan 4 | vsBrowns | L18-20 | 6-11 | .353 | Paycor Stadium · Cincinnati, OH |
