| 1 | Sun Sep 8 | vs Rams | W26-20 (OT) | 1-0 | 1.000 | Ford Field · Detroit, MI |
| 2 | Sun Sep 15 | vs Buccaneers | L16-20 | 1-1 | .500 | Ford Field · Detroit, MI |
| 3 | Sun Sep 22 | at Cardinals | W20-13 | 2-1 | .667 | State Farm Stadium · Glendale, AZ |
| 4 | Mon Sep 30 | vs Seahawks | W42-29 | 3-1 | .750 | Ford Field · Detroit, MI |
| 5 | -- BYE WEEK -- |
| 6 | Sun Oct 13 | at Cowboys | W47-9 | 4-1 | .800 | AT&T Stadium · Arlington, TX |
| 7 | Sun Oct 20 | at Vikings | W31-29 | 5-1 | .833 | U.S. Bank Stadium · Minneapolis, MN |
| 8 | Sun Oct 27 | vs Titans | W52-14 | 6-1 | .857 | Ford Field · Detroit, MI |
| 9 | Sun Nov 3 | at Packers | W24-14 | 7-1 | .875 | Lambeau Field · Green Bay, WI |
| 10 | Sun Nov 10 | at Texans | W26-23 | 8-1 | .889 | NRG Stadium · Houston, TX |
| 11 | Sun Nov 17 | vs Jaguars | W52-6 | 9-1 | .900 | Ford Field · Detroit, MI |
| 12 | Sun Nov 24 | at Colts | W24-6 | 10-1 | .909 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Thu Nov 28 | vs Bears | W23-20 | 11-1 | .917 | Ford Field · Detroit, MI |
| 14 | Thu Dec 5 | vsPackers | W34-31 | 12-1 | .923 | Ford Field · Detroit, MI |
| 15 | Sun Dec 15 | vs Bills | L42-48 | 12-2 | .857 | Ford Field · Detroit, MI |
| 16 | Sun Dec 22 | atBears | W34-17 | 13-2 | .867 | Soldier Field · Chicago, IL |
| 17 | Mon Dec 30 | at 49ers | W40-34 | 14-2 | .875 | Levi's® Stadium · Santa Clara, CA |
| 18 | Sun Jan 5 | vsVikings | W31-9 | 15-2 | .882 | Ford Field · Detroit, MI |
| DIV | Sat Jan 18 | vs Commanders | L31-45 | 15-2 | .882 | Ford Field · Detroit, MI |
