| 1 | Sun Sep 8 | at Cardinals | T27-27 (OT) | 0-0-1 | .000 | State Farm Stadium · Glendale, AZ |
| 2 | Sun Sep 15 | vs Chargers | W13-10 | 1-0-1 | 1.000 | Ford Field · Detroit, MI |
| 3 | Sun Sep 22 | at Eagles | W27-24 | 2-0-1 | 1.000 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sun Sep 29 | vs Chiefs | L30-34 | 2-1-1 | .667 | Ford Field · Detroit, MI |
| 5 | -- BYE WEEK -- |
| 6 | Mon Oct 14 | at Packers | L22-23 | 2-2-1 | .500 | Lambeau Field · Green Bay, WI |
| 7 | Sun Oct 20 | vs Vikings | L30-42 | 2-3-1 | .400 | Ford Field · Detroit, MI |
| 8 | Sun Oct 27 | vs Giants | W31-26 | 3-3-1 | .500 | Ford Field · Detroit, MI |
| 9 | Sun Nov 3 | at Raiders | L24-31 | 3-4-1 | .429 | Allegiant Stadium · Las Vegas, NV |
| 10 | Sun Nov 10 | at Bears | L13-20 | 3-5-1 | .375 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 17 | vs Cowboys | L27-35 | 3-6-1 | .333 | Ford Field · Detroit, MI |
| 12 | Sun Nov 24 | at Commanders | L16-19 | 3-7-1 | .300 | FedEx Field · North Englewood, MD |
| 13 | Thu Nov 28 | vsBears | L20-24 | 3-8-1 | .273 | Ford Field · Detroit, MI |
| 14 | Sun Dec 8 | atVikings | L7-20 | 3-9-1 | .250 | U.S. Bank Stadium · Minneapolis, MN |
| 15 | Sun Dec 15 | vs Buccaneers | L17-38 | 3-10-1 | .231 | Ford Field · Detroit, MI |
| 16 | Sun Dec 22 | at Broncos | L17-27 | 3-11-1 | .214 | Empower Field at Mile High · Denver, CO |
| 17 | Sun Dec 29 | vsPackers | L20-23 | 3-12-1 | .200 | Ford Field · Detroit, MI |
