| 1 | Sun Sep 13 | vs Bears | L23-27 | 0-1 | .000 | Ford Field · Detroit, MI |
| 2 | Sun Sep 20 | atPackers | L21-42 | 0-2 | .000 | Lambeau Field · Green Bay, WI |
| 3 | Sun Sep 27 | atCardinals | W26-23 | 1-2 | .333 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Oct 4 | vsSaints | L29-35 | 1-3 | .250 | Ford Field · Detroit, MI |
| --bye week-- |
| 6 | Sun Oct 18 | atJaguars | W34-16 | 2-3 | .400 | TIAA Bank Field · Jacksonville, FL |
| 7 | Sun Oct 25 | atFalcons | W23-22 | 3-3 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 8 | Sun Nov 1 | vsColts | L21-41 | 3-4 | .429 | Ford Field · Detroit, MI |
| 9 | Sun Nov 8 | atVikings | L20-34 | 3-5 | .375 | U.S. Bank Stadium · Minneapolis, MN |
| 10 | Sun Nov 15 | vsCommanders | W30-27 | 4-5 | .444 | Ford Field · Detroit, MI |
| 11 | Sun Nov 22 | atPanthers | L0-20 | 4-6 | .400 | Bank of America Stadium · Charlotte, NC |
| 12 | Thu Nov 26 | vsTexans | L25-41 | 4-7 | .364 | Ford Field · Detroit, MI |
| 13 | Sun Dec 6 | atBears | W34-30 | 5-7 | .417 | Soldier Field · Chicago, IL |
| 14 | Sun Dec 13 | vsPackers | L24-31 | 5-8 | .385 | Ford Field · Detroit, MI |
| 15 | Sun Dec 20 | atTitans | L25-46 | 5-9 | .357 | Nissan Stadium · Nashville, TN |
| 16 | Sat Dec 26 | vsBuccaneers | L7-47 | 5-10 | .333 | Ford Field · Detroit, MI |
| 17 | Sun Jan 3 | vsVikings | L35-37 | 5-11 | .313 | Ford Field · Detroit, MI |
