| 1 | Sun Sep 8 | vs Commanders | W37-20 | 1-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 2 | Sun Sep 15 | at Lions | W20-16 | 2-0 | 1.000 | Ford Field · Detroit, MI |
| 3 | Sun Sep 22 | vs Broncos | L7-26 | 2-1 | .667 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Sep 29 | vs Eagles | W33-16 | 3-1 | .750 | Raymond James Stadium · Tampa, FL |
| 5 | Thu Oct 3 | at Falcons | L30-36 (OT) | 3-2 | .600 | Mercedes-Benz Stadium · Atlanta, GA |
| 6 | Sun Oct 13 | at Saints | W51-27 | 4-2 | .667 | Caesars Superdome · New Orleans, LA |
| 7 | Mon Oct 21 | vs Ravens | L31-41 | 4-3 | .571 | Raymond James Stadium · Tampa, FL |
| 8 | Sun Oct 27 | vsFalcons | L26-31 | 4-4 | .500 | Raymond James Stadium · Tampa, FL |
| 9 | Mon Nov 4 | at Chiefs | L24-30 (OT) | 4-5 | .444 | Arrowhead Stadium · Kansas City, MO |
| 10 | Sun Nov 10 | vs 49ers | L20-23 | 4-6 | .400 | Raymond James Stadium · Tampa, FL |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 24 | at Giants | W30-7 | 5-6 | .455 | MetLife Stadium · East Rutherford, NJ |
| 13 | Sun Dec 1 | at Panthers | W26-23 (OT) | 6-6 | .500 | Bank of America Stadium · Charlotte, NC |
| 14 | Sun Dec 8 | vs Raiders | W28-13 | 7-6 | .538 | Raymond James Stadium · Tampa, FL |
| 15 | Sun Dec 15 | at Chargers | W40-17 | 8-6 | .571 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 22 | at Cowboys | L24-26 | 8-7 | .533 | AT&T Stadium · Arlington, TX |
| 17 | Sun Dec 29 | vsPanthers | W48-14 | 9-7 | .563 | Raymond James Stadium · Tampa, FL |
| 18 | Sun Jan 5 | vsSaints | W27-19 | 10-7 | .588 | Raymond James Stadium · Tampa, FL |
| WC | Sun Jan 12 | vsCommanders | L20-23 | 10-7 | .588 | Raymond James Stadium · Tampa, FL |
