| 1 | Sun Sep 7 | at Falcons | W23-20 | - | 1-0 | 1.000 | Mercedes-Benz Stadium · Atlanta, GA |
| 2 | Mon Sep 15 | atTexans | W20-19 | - | 2-0 | 1.000 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 21 | vsJets | W29-27 | - | 3-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Sep 28 | vsEagles | L25-31 | - | 3-1 | .750 | Raymond James Stadium · Tampa, FL |
| 5 | Sun Oct 5 | atSeahawks | W38-35 | - | 4-1 | .800 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 12 | vs49ers | W30-19 | - | 5-1 | .833 | Raymond James Stadium · Tampa, FL |
| 7 | Mon Oct 20 | atLions | L9-24 | - | 5-2 | .714 | Ford Field · Detroit, MI |
| 8 | Sun Oct 26 | atSaints | W23-3 | - | 6-2 | .750 | Caesars Superdome · New Orleans, LA |
| --bye week-- |
| 10 | Sun Nov 9 | vsPatriots | L23-28 | - | 6-3 | .667 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 16 | atBills | L32-44 | - | 6-4 | .600 | Highmark Stadium · Orchard Park, NY |
| 12 | Sun Nov 23 | atRams | L7-34 | - | 6-5 | .545 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Nov 30 | vsCardinals | W20-17 | - | 7-5 | .583 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 7 | vsSaints | L20-24 | - | 7-6 | .538 | Raymond James Stadium · Tampa, FL |
| 15 | Thu Dec 11 | vsFalcons | L28-29 | - | 7-7 | .500 | Raymond James Stadium · Tampa, FL |
| 16 | Sun Dec 21 | atPanthers | L20-23 | - | 7-8 | .467 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Dec 28 | atDolphins | L17-20 | - | 7-9 | .438 | Hard Rock Stadium · Miami Gardens, FL |
| 18 | Sat Jan 3 | vsPanthers | W16-14 | - | 8-9 | .471 | Raymond James Stadium · Tampa, FL |
