| 1 | Sun Sep 10 | at Vikings | W20-17 | - | 1-0 | 1.000 | U.S. Bank Stadium · Minneapolis, MN |
| 2 | Sun Sep 17 | vsBears | W27-17 | - | 2-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 3 | Mon Sep 25 | vsEagles | L11-25 | - | 2-1 | .667 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Oct 1 | atSaints | W26-9 | - | 3-1 | .750 | Caesars Superdome · New Orleans, LA |
| --bye week-- |
| 6 | Sun Oct 15 | vsLions | L6-20 | - | 3-2 | .600 | Raymond James Stadium · Tampa, FL |
| 7 | Sun Oct 22 | vsFalcons | L13-16 | - | 3-3 | .500 | Raymond James Stadium · Tampa, FL |
| 8 | Thu Oct 26 | atBills | L18-24 | - | 3-4 | .429 | Highmark Stadium · Orchard Park, NY |
| 9 | Sun Nov 5 | atTexans | L37-39 | - | 3-5 | .375 | NRG Stadium · Houston, TX |
| 10 | Sun Nov 12 | vsTitans | W20-6 | - | 4-5 | .444 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 19 | at49ers | L14-27 | - | 4-6 | .400 | Levi's® Stadium · Santa Clara, CA |
| 12 | Sun Nov 26 | atColts | L20-27 | - | 4-7 | .364 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Sun Dec 3 | vsPanthers | W21-18 | - | 5-7 | .417 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 10 | atFalcons | W29-25 | - | 6-7 | .462 | Mercedes-Benz Stadium · Atlanta, GA |
| 15 | Sun Dec 17 | atPackers | W34-20 | - | 7-7 | .500 | Lambeau Field · Green Bay, WI |
| 16 | Sun Dec 24 | vsJaguars | W30-12 | - | 8-7 | .533 | Raymond James Stadium · Tampa, FL |
| 17 | Sun Dec 31 | vsSaints | L13-23 | - | 8-8 | .500 | Raymond James Stadium · Tampa, FL |
| 18 | Sun Jan 7 | atPanthers | W9-0 | - | 9-8 | .529 | Bank of America Stadium · Charlotte, NC |
| WC | Mon Jan 15 | vsEagles | W32-9 | - | 9-8 | .529 | Raymond James Stadium · Tampa, FL |
| DIV | Sun Jan 21 | atLions | L23-31 | - | 9-8 | .529 | Ford Field · Detroit, MI |
