| 1 | Thu Sep 9 | vs Cowboys | W31-29 | - | 1-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 2 | Sun Sep 19 | vsFalcons | W48-25 | - | 2-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 3 | Sun Sep 26 | atRams | L24-34 | - | 2-1 | .667 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 3 | atPatriots | W19-17 | - | 3-1 | .750 | Gillette Stadium · Foxborough, MA |
| 5 | Sun Oct 10 | vsDolphins | W45-17 | - | 4-1 | .800 | Raymond James Stadium · Tampa, FL |
| 6 | Thu Oct 14 | atEagles | W28-22 | - | 5-1 | .833 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Sun Oct 24 | vsBears | W38-3 | - | 6-1 | .857 | Raymond James Stadium · Tampa, FL |
| 8 | Sun Oct 31 | atSaints | L27-36 | - | 6-2 | .750 | Caesars Superdome · New Orleans, LA |
| --bye week-- |
| 10 | Sun Nov 14 | atCommanders | L19-29 | - | 6-3 | .667 | FedEx Field · North Englewood, MD |
| 11 | Mon Nov 22 | vsGiants | W30-10 | - | 7-3 | .700 | Raymond James Stadium · Tampa, FL |
| 12 | Sun Nov 28 | atColts | W38-31 | - | 8-3 | .727 | Lucas Oil Stadium · Indianapolis, IN |
| 13 | Sun Dec 5 | atFalcons | W30-17 | - | 9-3 | .750 | Mercedes-Benz Stadium · Atlanta, GA |
| 14 | Sun Dec 12 | vsBills | W33-27 (OT) | - | 10-3 | .769 | Raymond James Stadium · Tampa, FL |
| 15 | Sun Dec 19 | vsSaints | L0-9 | - | 10-4 | .714 | Raymond James Stadium · Tampa, FL |
| 16 | Sun Dec 26 | atPanthers | W32-6 | - | 11-4 | .733 | Bank of America Stadium · Charlotte, NC |
| 17 | Sun Jan 2 | atJets | W28-24 | - | 12-4 | .750 | MetLife Stadium · East Rutherford, NJ |
| 18 | Sun Jan 9 | vsPanthers | W41-17 | - | 13-4 | .765 | Raymond James Stadium · Tampa, FL |
| WC | Sun Jan 16 | vsEagles | W31-15 | - | 13-4 | .765 | Raymond James Stadium · Tampa, FL |
| DIV | Sun Jan 23 | vsRams | L27-30 | - | 13-4 | .765 | Raymond James Stadium · Tampa, FL |
