| 1 | Sun Sep 11 | at Cowboys | W19-3 | 1-0 | 1.000 | AT&T Stadium · Arlington, TX |
| 2 | Sun Sep 18 | atSaints | W20-10 | 2-0 | 1.000 | Caesars Superdome · New Orleans, LA |
| 3 | Sun Sep 25 | vsPackers | L12-14 | 2-1 | .667 | Raymond James Stadium · Tampa, FL |
| 4 | Sun Oct 2 | vsChiefs | L31-41 | 2-2 | .500 | Raymond James Stadium · Tampa, FL |
| 5 | Sun Oct 9 | vsFalcons | W21-15 | 3-2 | .600 | Raymond James Stadium · Tampa, FL |
| 6 | Sun Oct 16 | atSteelers | L18-20 | 3-3 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sun Oct 23 | atPanthers | L3-21 | 3-4 | .429 | Bank of America Stadium · Charlotte, NC |
| 8 | Thu Oct 27 | vsRavens | L22-27 | 3-5 | .375 | Raymond James Stadium · Tampa, FL |
| 9 | Sun Nov 6 | vsRams | W16-13 | 4-5 | .444 | Raymond James Stadium · Tampa, FL |
| 10 | Sun Nov 13 | vsSeahawks | W21-16 | 5-5 | .500 | Raymond James Stadium · Tampa, FL |
| --bye week-- |
| 12 | Sun Nov 27 | atBrowns | L17-23 (OT) | 5-6 | .455 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Mon Dec 5 | vsSaints | W17-16 | 6-6 | .500 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 11 | at49ers | L7-35 | 6-7 | .462 | Levi's® Stadium · Santa Clara, CA |
| 15 | Sun Dec 18 | vsBengals | L23-34 | 6-8 | .429 | Raymond James Stadium · Tampa, FL |
| 16 | Sun Dec 25 | atCardinals | W19-16 (OT) | 7-8 | .467 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Jan 1 | vsPanthers | W30-24 | 8-8 | .500 | Raymond James Stadium · Tampa, FL |
| 18 | Sun Jan 8 | atFalcons | L17-30 | 8-9 | .471 | Mercedes-Benz Stadium · Atlanta, GA |
| WC | Mon Jan 16 | vsCowboys | L14-31 | 8-9 | .471 | Raymond James Stadium · Tampa, FL |
