| 1 | Thu Sep 10 | at Rams | 8:35 PM | 0-0 | .000 | Melbourne Cricket Ground · Melbourne, AUS |
| 2 | Sun Sep 20 | vsDolphins | 4:25 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 3 | Sun Sep 27 | vsCardinals | 4:05 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 4 | Sun Oct 4 | vsBroncos | 4:25 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 11 | atSeahawks | 4:25 PM | 0-0 | .000 | Lumen Field · Seattle, WA |
| 6 | Mon Oct 19 | vsCommanders | 8:15 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 7 | Sun Oct 25 | atFalcons | 1:00 PM | 0-0 | .000 | Mercedes-Benz Stadium · Atlanta, GA |
| --bye week-- |
| 9 | Sun Nov 8 | vsRaiders | 4:05 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 10 | Sun Nov 15 | atCowboys | 4:25 PM | 0-0 | .000 | AT&T Stadium · Arlington, TX |
| 11 | Sun Nov 22 | vsVikings | 8:20 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 12 | Sun Nov 29 | vsSeahawks | 4:25 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 13 | Sun Dec 6 | atGiants | 1:00 PM | 0-0 | .000 | MetLife Stadium · East Rutherford, NJ |
| 14 | Sun Dec 13 | vsRams | 4:25 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 15 | Thu Dec 17 | atChargers | 8:15 PM | 0-0 | .000 | SoFi Stadium · Inglewood, CA |
| 16 | Sun Dec 27 | atChiefs | 4:25 PM | 0-0 | .000 | Arrowhead Stadium · Kansas City, MO |
| 17 | Sun Jan 3 | vsEagles | 8:20 PM | 0-0 | .000 | Levi's® Stadium · Santa Clara, CA |
| 18 | TBD | atCardinals | TBD | 0-0 | .000 | State Farm Stadium · Glendale, AZ |
