| 3 | Sun Sep 21 | vs Cardinals | 4:25 PM | 2-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 4 | Sun Sep 28 | vsJaguars | 4:05 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 5 | Thu Oct 2 | atRams | 8:15 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 12 | atBuccaneers | 1:00 PM | 2-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 7 | Sun Oct 19 | vsFalcons | 8:20 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 8 | Sun Oct 26 | atTexans | 1:00 PM | 0-2 | .000 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 2 | atGiants | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 9 | vsRams | 4:25 PM | 2-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 11 | Sun Nov 16 | atCardinals | 4:05 PM | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 12 | Mon Nov 24 | vsPanthers | 8:15 PM | 0-2 | .000 | Levi's® Stadium · Santa Clara, CA |
| 13 | Sun Nov 30 | atBrowns | 1:00 PM | 0-2 | .000 | FirstEnergy Stadium · Cleveland, OH |
| --bye week-- |
| 15 | Sun Dec 14 | vsTitans | 4:25 PM | 0-2 | .000 | Levi's® Stadium · Santa Clara, CA |
| 16 | Mon Dec 22 | atColts | 8:15 PM | 2-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Dec 28 | vsBears | 8:20 PM | 0-2 | .000 | Levi's® Stadium · Santa Clara, CA |
| 18 | TBD | vsSeahawks | TBD | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
