| 3 | Sun Sep 22 | at Rams | 4:25 PM | 0-2 | .000 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Sep 29 | vs Patriots | 4:05 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 6 | vs Cardinals | 4:05 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 6 | Thu Oct 10 | at Seahawks | 8:15 PM | 2-0 | 1.000 | Lumen Field · Seattle, WA |
| 7 | Sun Oct 20 | vs Chiefs | 4:25 PM | 2-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 8 | Sun Oct 27 | vs Cowboys | 8:20 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 10 | Sun Nov 10 | at Buccaneers | 1:00 PM | 2-0 | 1.000 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 17 | vsSeahawks | 4:05 PM | 2-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 12 | Sun Nov 24 | at Packers | 4:25 PM | 1-1 | .500 | Lambeau Field · Green Bay, WI |
| 13 | Sun Dec 1 | at Bills | 8:20 PM | 2-0 | 1.000 | Highmark Stadium · Orchard Park, NY |
| 14 | Sun Dec 8 | vs Bears | 4:25 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 15 | Thu Dec 12 | vsRams | 8:15 PM | 0-2 | .000 | Levi's® Stadium · Santa Clara, CA |
| 16 | Sun Dec 22 | at Dolphins | 4:25 PM | 1-1 | .500 | Hard Rock Stadium · Miami Gardens, FL |
| 17 | Mon Dec 30 | vs Lions | 8:15 PM | 1-1 | .500 | Levi's® Stadium · Santa Clara, CA |
| 18 | TBD | atCardinals | TBD | 1-1 | .500 | State Farm Stadium · Glendale, AZ |
Vikings
Jets