| 3 | Sun Sep 21 | vs Broncos | 4:05 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Sep 28 | atGiants | 1:00 PM | 0-2 | .000 | MetLife Stadium · East Rutherford, NJ |
| 5 | Sun Oct 5 | vsCommanders | 4:25 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 6 | Sun Oct 12 | atDolphins | 1:00 PM | 0-2 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 7 | Sun Oct 19 | vsColts | 4:05 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 8 | Thu Oct 23 | vsVikings | 8:15 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 2 | atTitans | 1:00 PM | 0-2 | .000 | Nissan Stadium · Nashville, TN |
| 10 | Sun Nov 9 | vsSteelers | 8:20 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 16 | atJaguars | 1:00 PM | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| --bye week-- |
| 13 | Sun Nov 30 | vsRaiders | 4:25 PM | 1-1 | .500 | SoFi Stadium · Inglewood, CA |
| 14 | Mon Dec 8 | vsEagles | 8:15 PM | 2-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 14 | atChiefs | 1:00 PM | 0-2 | .000 | Arrowhead Stadium · Kansas City, MO |
| 16 | Sun Dec 21 | atCowboys | 1:00 PM | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 17 | TBD | vsTexans | TBD | 0-2 | .000 | SoFi Stadium · Inglewood, CA |
