| 1 | Sun Sep 11 | vs Raiders | W24-19 | 1-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 2 | Thu Sep 15 | atChiefs | L24-27 | 1-1 | .500 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 25 | vsJaguars | L10-38 | 1-2 | .333 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 2 | atTexans | W34-24 | 2-2 | .500 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 9 | atBrowns | W30-28 | 3-2 | .600 | FirstEnergy Stadium · Cleveland, OH |
| 6 | Mon Oct 17 | vsBroncos | W19-16 (OT) | 4-2 | .667 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 23 | vsSeahawks | L23-37 | 4-3 | .571 | SoFi Stadium · Inglewood, CA |
| --bye week-- |
| 9 | Sun Nov 6 | atFalcons | W20-17 | 5-3 | .625 | Mercedes-Benz Stadium · Atlanta, GA |
| 10 | Sun Nov 13 | at49ers | L16-22 | 5-4 | .556 | Levi's® Stadium · Santa Clara, CA |
| 11 | Sun Nov 20 | vsChiefs | L27-30 | 5-5 | .500 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 27 | atCardinals | W25-24 | 6-5 | .545 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Dec 4 | atRaiders | L20-27 | 6-6 | .500 | Allegiant Stadium · Las Vegas, NV |
| 14 | Sun Dec 11 | vsDolphins | W23-17 | 7-6 | .538 | SoFi Stadium · Inglewood, CA |
| 15 | Sun Dec 18 | vsTitans | W17-14 | 8-6 | .571 | SoFi Stadium · Inglewood, CA |
| 16 | Mon Dec 26 | atColts | W20-3 | 9-6 | .600 | Lucas Oil Stadium · Indianapolis, IN |
| 17 | Sun Jan 1 | vsRams | W31-10 | 10-6 | .625 | SoFi Stadium · Inglewood, CA |
| 18 | Sun Jan 8 | atBroncos | L28-31 | 10-7 | .588 | Empower Field at Mile High · Denver, CO |
| WC | Sat Jan 14 | atJaguars | L30-31 | 10-7 | .588 | TIAA Bank Field · Jacksonville, FL |
