| 1 | Sun Sep 8 | vs Raiders | W22-10 | 1-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 15 | atPanthers | W26-3 | 2-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 3 | Sun Sep 22 | atSteelers | L10-20 | 2-1 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sun Sep 29 | vsChiefs | L10-17 | 2-2 | .500 | SoFi Stadium · Inglewood, CA |
| --bye week-- |
| 6 | Sun Oct 13 | atBroncos | W23-16 | 3-2 | .600 | Empower Field at Mile High · Denver, CO |
| 7 | Mon Oct 21 | atCardinals | L15-17 | 3-3 | .500 | State Farm Stadium · Glendale, AZ |
| 8 | Sun Oct 27 | vsSaints | W26-8 | 4-3 | .571 | SoFi Stadium · Inglewood, CA |
| 9 | Sun Nov 3 | atBrowns | W27-10 | 5-3 | .625 | FirstEnergy Stadium · Cleveland, OH |
| 10 | Sun Nov 10 | vsTitans | W27-17 | 6-3 | .667 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 17 | vsBengals | W34-27 | 7-3 | .700 | SoFi Stadium · Inglewood, CA |
| 12 | Mon Nov 25 | vsRavens | L23-30 | 7-4 | .636 | SoFi Stadium · Inglewood, CA |
| 13 | Sun Dec 1 | atFalcons | W17-13 | 8-4 | .667 | Mercedes-Benz Stadium · Atlanta, GA |
| 14 | Sun Dec 8 | atChiefs | L17-19 | 8-5 | .615 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 15 | vsBuccaneers | L17-40 | 8-6 | .571 | SoFi Stadium · Inglewood, CA |
| 16 | Thu Dec 19 | vsBroncos | W34-27 | 9-6 | .600 | SoFi Stadium · Inglewood, CA |
| 17 | Sat Dec 28 | atPatriots | W40-7 | 10-6 | .625 | Gillette Stadium · Foxborough, MA |
| 18 | Sun Jan 5 | atRaiders | W34-20 | 11-6 | .647 | Allegiant Stadium · Las Vegas, NV |
| WC | Sat Jan 11 | atTexans | L12-32 | 11-6 | .647 | NRG Stadium · Houston, TX |
